AI Article Synopsis
- The study investigates how metabolic syndrome (MetS) affects the relationship between cognitive abilities and frailty in individuals aged 50 and above.
- Results show that MetS significantly increases the chances of being frail, with better episodic memory linked to lower chances of having MetS, while worse executive function correlates with higher frailty.
- The findings highlight that MetS enhances the negative impact of executive function on frailty, suggesting the need for future research to explore interventions for those with MetS to improve cognitive function and reduce frailty.
Article Abstract
Objectives: This study examined whether metabolic syndrome (MetS) would moderate the association of cognition with frailty in middle and old age.
Methods: A cross-sectional design was used. Six hundred and ninety participants (age ≥ 50 years) from an on-going national survey were included in the study. Confirmatory factor analysis was applied to determine latent variables of executive function (EF), episodic memory (EM), and MetS based on relevant measurements. Frailty was defined using a modified form of Fried's criteria.
Results: Applying structural equation modeling, having MetS significantly increased the likelihood of being frail. Better performance on EM tasks, but not EF, was significantly associated with lower likelihood of MetS. Worse performance on EF, but not EM, significantly increased the likelihood of being frail. There was a significant interacting effect between MetS and EF, but not EM, on frailty. Further contrast analysis indicated that having MetS strengthened the negative association between EF and frailty.
Conclusion: Metabolic syndrome moderates the relationship between EF and frailty. A prospecitve study is needed to validate such relationships before developing interventions targeting the prevention or treatment of EF and frailty in individuals with MetS.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198518 | PMC |
| http://dx.doi.org/10.1002/gps.4115 | DOI Listing |
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