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The evidence base for rotavirus vaccination in India: Current status, future needs.
Vaccine
January 2025
Division of Gastrointestinal Sciences, The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu 632004, India.
Rotavirus is a leading cause of severe diarrheal disease in infants and young children worldwide. Vaccination offers the best protection against this disease, and two rotavirus vaccines were developed in India and included in its routine immunization program. The Government of India's decision to adopt this intervention was supported by a solid base of evidence from clinical trials, as well as substantial research regarding rotavirus disease burden and the potential health and economic value of immunization.
View Article and Find Full Text PDFThe Apparent Lack of the Risk of Intussusception Immediately After Rotavirus Vaccination Among Japanese Infants.
Viruses
November 2024
Department of Pediatrics, Akita University Graduate School of Medicine, Akita-shi 010-8543, Japan.
Rotavirus vaccines carry a small risk of intussusception mainly 1-7 days after vaccination in the United States of America, Europe, Australia, and Latin America where the background rate of intussusception is relatively low. Such risks are undetectable in Africa and India where the background rate is the lowest. Because few studies were carried out in high-background-rate countries such as Japan, we examined how intussusception occurred in infants living in Akita prefecture, Japan, while the vaccines were sold in the private market.
View Article and Find Full Text PDFInfectious etiology of intussusception in Indian children less than 2 years old: a matched case-control analysis.
Gut Pathog
October 2024
The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Background: Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens.
View Article and Find Full Text PDFRotavirus vaccination is a protective factor for adverse outcomes in primary intussusception: a single-center retrospective study.
Transl Pediatr
June 2024
Department of Pediatric Gastroenterology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Article Synopsis
- A study was conducted to analyze the clinical features and outcomes of intussusception in children who received the rotavirus vaccine compared to those who did not, involving 327 patients from 2019 to 2021.
- The vaccinated group showed a higher success rate for non-surgical treatment (air enema reduction) and experienced fewer surgeries and complications than the control group.
- Findings indicated that rotavirus vaccination acted as a protective factor against adverse events, with lower inflammatory biomarker levels observed in vaccinated patients.
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