Evaluation of avibactam-supplemented combination disk tests for the detection of OXA-48 carbapenemase-producing Enterobacteriaceae.

Diagn Microbiol Infect Dis

National Reference Laboratory for Monitoring of Antimicrobial Resistance in Gram-negative bacteria, CHU Dinant-Godinne|UCL Namur, 1 Avenue Dr. G. Therasse, 5530 Yvoir, Belgium.

Published: June 2014

The ability of various combination disk tests (CDTs) incorporating avibactam to detect OXA-48 carbapenemase-producing Enterobacteriaceae was evaluated. The CDT using 30-μg temocillin alone and supplemented with 5-μg avibactam showed good performance and could be an adjunctive test to the classic CDT containing class A and class B carbapenemase inhibitors for the positive discrimination of OXA-48 carbapenemase producers from carbapenemase-negative strains.

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http://dx.doi.org/10.1016/j.diagmicrobio.2014.03.010DOI Listing

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