The thorny problem of dyskinesias: dendritic spines, synaptic plasticity, and striatal dysfunction.

Biol Psychiatry

Departments of Psychiatry and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

Published: May 2014

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120525PMC
http://dx.doi.org/10.1016/j.biopsych.2014.02.019DOI Listing

Publication Analysis

Top Keywords

thorny problem
4
problem dyskinesias
4
dyskinesias dendritic
4
dendritic spines
4
spines synaptic
4
synaptic plasticity
4
plasticity striatal
4
striatal dysfunction
4
thorny
1
dyskinesias
1

Similar Publications

Differences in Blood and Cerebrospinal Fluid Between Parkinson's Disease and Related Diseases.

Cell Mol Neurobiol

December 2024

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

It is difficult to distinguish Parkinson's disease (PD) in the early stage from those of various disorders including atypical Parkinson's syndrome (APS), vascular parkinsonism (VP), and even essential tremor (ET), because of the overlap of symptoms. Other, more challenging problems will arise when Parkinson's disease develops into Parkinson's disease dementia (PDD) in the middle and late stages. At this time, the differential diagnosis of PDD and DLB becomes thorny.

View Article and Find Full Text PDF

Developing a novel antibacterial coating system for marine corrosion and fouling control.

Mar Pollut Bull

January 2025

Beijing Key Laboratory of Electrochemical Processes and Technology of Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:

Microbial-influenced corrosion and marine biofouling have become a thorny problem restricting the effective long-term operation of marine engineering. In this study, a novel antibacterial coating system for marine corrosion and fouling control was developed to integrate and improve the antibacterial performance. The coating system was composed of an epoxy primer and a low surface energy organosilicon/polyurethane topcoat, while quaternary ammonium salt (QAS) was added as an antimicrobial agent.

View Article and Find Full Text PDF

Background: Platinum-based chemotherapy is one of the main treatments for lung adenocarcinoma (LUAD). However, the toxic side effects and drug resistance of chemotherapeutic drugs on normal cells are still a thorny problem in clinical treatment. Dendrobium is one of the three largest genera of Orchidaceous family, which has ornamental and medicinal value.

View Article and Find Full Text PDF

"In Mathematical Language": On Mathematical Foundations of Quantum Foundations.

Entropy (Basel)

November 2024

Literature, Theory, and Cultural Studies, and Philosophy and Literature Program, Purdue University, West Lafayette, IN 47907, USA.

The argument of this article is threefold. First, the article argues that from its rise in the sixteenth century to our own time, the advancement of modern physics as mathematical-experimental science has been defined by the invention of Second, the article argues that quantum theory, especially following quantum mechanics, gives this thesis a radically new meaning by virtue of the following two features: on the one hand, quantum phenomena are defined as essentially different from those found in all previous physics by ; and on the other, quantum mechanics and quantum field theory are defined by , which connect them to quantum phenomena strictly in terms of probabilities, without, as in all previous physics, representing or otherwise relating to how these phenomena physically come about. While these two features may appear discordant, if not inconsistent, I argue that they are in accord with each other, at least in certain interpretations (including the one adopted here), designated as "reality without realism", RWR, interpretations.

View Article and Find Full Text PDF
Article Synopsis
  • - Rural areas are shifting away from agriculture, which threatens farmland and global food security; a study focused on farmers in hilly regions revealed significant insights into their risk preferences and livelihood changes.
  • - Most rural households showed risk aversion, with 76.86% preferring safer options, and those focused on non-agricultural activities were found to be the most risk-averse compared to others.
  • - The study suggests that while moving away from agriculture can lead to higher profits and lower risks for some farmers, it may also create financial burdens; recommendations for a sustainable transition were offered.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!