AI Article Synopsis
- - The text describes a new method to synthesize Amadori ketoses using N-(1-deoxy-D-fructose-1-yl) amino acids with L-valine, L-leucine, L-isoleucine, L-tryptophan, L-phenylalanine, and L-arginine.
- - This synthesis uses ZnCl2 as a catalyst, making the process more efficient by eliminating the need for protection/deprotection and complex purification techniques like ion-exchange and column chromatography.
- - The resulting Amadori ketoses were found to exhibit moderate to weak activity in inhibiting angiotensin I converting enzyme (ACE), which is important for regulating blood pressure.
Article Abstract
An efficient and practical protocol for the synthesis of Amadori ketoses N-(1-deoxy-D-fructose-1-yl) amino acid (amino acid=L-valine (1), L-leucine (2), L-isoleucine (3), L-tryptophan (4), L-phenylalanine (5), L-arginine (6) has been accomplished by employing ZnCl2 as a catalyst. The developed method circumvents protection and deprotection steps as well as tedious ion-exchange and column chromatographic techniques. The accomplished Amadori ketoses showed moderate to weak angiotensin I converting enzyme (ACE) inhibitory activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.foodchem.2014.02.094 | DOI Listing |
Publication Analysis
Top Keywords
amadori ketoses
12
practical protocol
8
protocol synthesis
8
synthesis amadori
8
zncl2-mediated practical
4
ketoses efficient
4
efficient practical
4
ketoses n-1-deoxy-d-fructose-1-yl
4
n-1-deoxy-d-fructose-1-yl amino
4
amino acid
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!