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Surveillance of antimicrobial resistance using isothermal amplification: a review.
Chem Commun (Camb)
January 2025
State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road #13, Wuhan, Hubei 430030, China.
The monitoring of antibiotic resistance genes (ARGs) is crucial for understanding the level of antimicrobial resistance and the associated health burden, which in turn is essential for the control and prevention of antimicrobial resistance (AMR). Isothermal amplification, an emerging molecular biology technology, has been widely used for drug resistance detection. Furthermore, its compatibility with a range of technologies enables high-specificity, high-throughput, and portable and integrated detection in drug resistance, particularly in resource-limited areas.
View Article and Find Full Text PDFPersistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder.
Psychopharmacol Bull
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Frye, MD, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Bipolar disorder is a chronic disease that imposes a lifelong burden on those that suffer from it. Lithium is still considered both gold standard treatment and first-line maintenance treatment, and access to treatment with lithium is paramount to improving patient outcomes. However, access to adequate treatment is not only contingent on symptom recognition, accurate diagnosis, and individualization of treatment, but also affected by racial and ethnic disparities at each stage of patient experience.
View Article and Find Full Text PDFPrevalence of Substance Use and Sleep-Related Problems Among Driver Victims Involved in Road Traffic Accidents Presenting to a Tertiary Care Hospital in India.
Cureus
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Department of Psychiatry, All India Institute of Medical Sciences, Kalyani, Kalyani, IND.
Background: Road traffic accidents (RTAs) are a critical public health problem leading to significant morbidity, mortality, and socioeconomic losses. Despite known risk factors like substance use and sleep-related problems, there is limited research on the prevalence of these factors among drivers who met with RTAs. Hence, this study aimed to gain insight into the prevalence of substance use and sleep-related problems among this population attending a trauma center in the northern State of India.
View Article and Find Full Text PDFCD63 as novel target for nanoemulsion-based F MRI imaging and drug delivery to activated cardiac fibroblasts.
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Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Cardiac fibroblasts are activated following myocardial infarction (MI) and cardiac fibrosis is a major driver of the growing burden of heart failure. A non-invasive targeting method for activated cardiac fibroblasts would be advantageous because of their importance for imaging and therapy. Targeting was achieved by linking a 7-amino acid peptide (EP9) to a perfluorocarbon-containing nanoemulsion (PFC-NE) for visualization by F-combined with H-MRI.
View Article and Find Full Text PDFGlobal consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).
J Nutr Health Aging
December 2024
Faculty of Medicine and Health, School of Health Sciences and Sydney Medical School, University of Sydney, New South Wales, Australia, and Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, United States.
Article Synopsis
- Aging leads to physiological changes and increased disease vulnerability, culminating in higher mortality rates as individuals get older.
- Regular physical activity (PA) and exercise can counteract aging effects, improve health span, and reduce the risk of chronic diseases such as heart disease and cancer.
- Personalized exercise plans, including various forms of training like aerobic and resistance exercises, are essential for maintaining health and functionality in older adults, particularly those with age-related issues.
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