AI Article Synopsis
- Copper-catalyzed methods enable the C-2 arylation and vinylation of indole derivatives using iodonium salts, allowing for direct functionalization.
- The process is straightforward, operates under mild conditions, and accommodates a wide range of substrates, producing versatile indole derivatives.
- Additionally, excess iodonium salts facilitate a cascade reaction that includes C-2 arylation and dearomatization via C-3 arylation.
Article Abstract
Copper-catalyzed C-2 arylation and vinylation of indole derivatives with iodonium salts have been realized. This method, featuring a simple operational procedure, mild reaction conditions, and a wide substrate scope, provided versatile indole derivatives with direct and selective functionalization at the C-2 position of the indole core. In the presence of excess amounts of iodonium salts, cascade C-2 arylation and dearomatization through the C-3 arylation reaction also proceeded smoothly.
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| http://dx.doi.org/10.1002/asia.201402071 | DOI Listing |
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