We report the case of a young woman who presented with progressive dysphagia and swelling in the anterior aspect of the neck of short duration. On evaluation, she was diagnosed with amelanotic malignant melanoma of the cervical oesophagus. She underwent total laryngopharyngo-oesophagectomy with gastric transposition with bilateral modified radical neck dissection with feeding jejunostomy and a permanent tracheostomy with postoperative combined chemoradiation therapy. However, in spite of aggressive treatment, the patient expired 8 months after initial presentation with distant metastasis.
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http://dx.doi.org/10.1136/bcr-2014-204182 | DOI Listing |
Cancers (Basel)
December 2024
SydPath, St Vincent's Hospital Sydney, Darlinghurst, NSW 2010, Australia.
: Uveal melanomas (UMs) are rare but often deadly malignancies that urgently require viable treatment options. UMs often exhibit tumour heterogeneity, with macroscopic and microscopic differences in morphology between different regions of the same tumour. However, to date, the clinical significance of this and how it may help guide personalised therapy have not been realised.
View Article and Find Full Text PDFCureus
October 2024
General Surgery, SRM Medical College Hospital and Research Centre, Chennai, IND.
Anorectal malignant melanoma (ARMM) is a rare and highly aggressive type of melanoma that originates in the anorectal area. It represents a small fraction of all melanoma cases and is often associated with poor prognosis due to its late presentation and challenging treatment options. Rectal malignant melanoma typically presents with symptoms such as rectal bleeding, pain, and obstructive symptoms.
View Article and Find Full Text PDFAn Bras Dermatol
January 2025
Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Dermatology Unity, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Background: Acral melanomas (AM) are rare and approximately two-thirds of them occur on the soles of the feet beeing more prevalent in black and Asian individuals. Data on this subtype of melanoma are scarce in the Brazilian population.
Objectives: To describe and correlate the epidemiological, clinical, dermoscopic, and histopathological features of AM a.
Molecules
November 2024
Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-067 Bydgoszcz, Poland.
Melanoma occurs in various forms and body areas, not only in the cutis, but also in mucous membranes and the uvea. Rarer subtypes of that cancer differ in genomic aberrations, which cause their minor sensibility to regular cutaneous melanoma therapies. Therefore, it is essential to discover new strategies for treating rare forms of melanoma.
View Article and Find Full Text PDFInt J Mol Sci
October 2024
Department of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
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