Two novel bis(chromophoric) dyads ABPI-NI1 and ABPI-NI2 containing 1,8-naphthalimide and bacteriopurpurinimide units linked by p-phenylene-methylene (ABPI-NI1) and pentamethylene (ABPI-NI2) spacers were prepared to test their ability to be used in the design of effective agents for both photodynamic therapy (PDT) and fluorescent tumor imaging. Photophysical studies revealed that the emission from the naphthalimide chromophore in both conjugates was partially quenched due to resonance energy transfer between the photoactive components. Compound ABPI-NI2 with more sterically flexible oligomethylene group demonstrated higher fluorescence intensity as compared with that for ABPI-NI1.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jphotobiol.2014.03.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study.
BMJ Oncol
August 2023
Urology, University College London Hospitals NHS Foundation Trust, London, UK.
Objective: In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA in a formal screening study. We report a systematic community-based assessment of the prevalence of prostate MRI lesions in an age-selected population.
View Article and Find Full Text PDFWater-Soluble Mn(III)-Porphyrins with High Relaxivity and Photosensitization.
Chem Biomed Imaging
January 2025
Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 3, CH-8093 Zürich, Switzerland.
Three water-soluble Mn(III)-porphyrin complexes with cationic pyridyl side groups bearing COOH- or OH-terminated carbon chains in the meta or para positions have been synthesized as probes for both magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The complexes , , and are highly water-soluble, and their relaxivities range between 10 and 15 mM s, at 20-80 MHz and 298 K, 2-3 times higher than that of commercial Gd(III)-based agents. The complexes containing carboxylate () or alcoholic () side chains in the para position are endowed with higher relaxivities and have also shown efficient photoinduced DNA cleavage and singlet oxygen (O) generation.
View Article and Find Full Text PDFTwo-stage diffuse fluorescence tomography for monitoring of drug distribution in photodynamic therapy of tumors.
J Biomed Opt
January 2025
Lund University, Department of Physics, Lund, Sweden.
Significance: The spatial distribution of the photosensitizing drug concentration is an important parameter for predicting the photodynamic therapy (PDT) outcome. Current diffuse fluorescence tomography methods lack accuracy in quantifying drug concentration. The development of accurate methods for monitoring the temporal evolution of the drug distribution in tissue can advance the real-time light dosimetry in PDT of tumors, leading to better treatment outcomes.
View Article and Find Full Text PDFA free-radical initiator-based carrier-free smart nanobomb for targeted synergistic therapy of hypoxic breast cancer.
RSC Adv
January 2025
State Key Laboratory for New Textile Materials & Advanced Processing Technology, Wuhan Textile University Wuhan 430200 P. R. China
Thermodynamic therapy (TDT) is a promising alternative to photodynamic therapy (PDT) by absorbing heat through thermosensitive agents (TSAs) to generate oxygen-irrelevant highly toxic free radicals. Therefore, TDT can be a perfect partner for photothermal therapy (PTT) to achieve efficient synergistic treatment of anoxic tumors using a single laser, greatly simplifying the treatment process and overcoming hypoxia limitations. However, the issues of how to improve the stability and delivery efficiency of TSAs still need to be addressed urgently.
View Article and Find Full Text PDFDyad System of BOAHY-BODIPY Conjugates as Novel Photoswitchable Photosensitizers for Photodynamic Therapy.
J Med Chem
January 2025
Department of Pharmacology, Korea University College of Medicine, Korea University, Seoul 02841, South Korea.
Photodynamic therapy (PDT) offers minimally invasive and repeatable cancer treatment options. Despite advancements in photosensitizer (PS) design, the optical control of PS activation remains unexplored. Here, we present the first photoswitchable PS based on a BOAHY-BODIPY dyad system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!