AI Article Synopsis
- A pooled analysis reviewed data from six clinical trials involving tigecycline for treating MRSA soft tissue infections, including diabetic foot infections.
- Among 378 participants, 249 were identified as having community-acquired MRSA, particularly strain SCCmec IV.
- Results showed that tigecycline was as effective as vancomycin for MRSA infections, with similar clinical response rates across different infection types and molecular classifications.
Article Abstract
Given increasing resistance, therapeutic options to treat MRSA soft tissue infections should be evaluated. This pooled analysis evaluated data from subjects enrolled in 6 tigecycline clinical trials with documented MRSA complicated skin and skin structure infections or diabetic foot infections (DFIs). Baseline characteristics were compared between subjects with and without molecularly classified community-acquired (CA) MRSA, specifically staphylococcal cassette chromosome mec (SCCmec) IV. Clinical response was compared by CA-MRSA designation and treatment group. A total of 378 subjects with MRSA soft tissue infections were identified, including 79 with DFI. A total of 249 (65.9%) were molecularly classified as CA-MRSA. Clinical response rates for MRSA soft tissue infection were similar between tigecycline and vancomycin (treatment difference, 1.0%; 95% confidence interval: -9.3, 12.0) as well as by infection type, SCCmec, and Panton-Valentine leukocidin (PVL) status. Tigecycline demonstrated comparable efficacy for treatment of MRSA soft tissue infections regardless of infection type, SCCmec, or PVL status.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2014.03.001 | DOI Listing |
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