Objective: Our objective was to study the ontogeny of the superior semicircular canal in order to describe its peculiarities.
Methods: We analyzed 76 series of human embryos aged between 32 days (6mm) and newborns. The samples were cut serially and stained using Martin's trichrome technique.
Results: In semicircular canal development there were a number of peculiarities, such as: a defined chronological sequence of osteogenesis with a variable rate of ossification; the fact that each nucleus of ossification was involved in the formation of one of its covers (the upper in the superficial and the lower in the deep); the appearance of transitory dehiscence; and canal closure by means of bone with laminar pattern, with a minimum thickness of 0.1mm.
Conclusion: The peculiarities in canal development could explain the origin of pathological dehiscence in the canal, whether congenital or acquired.
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http://dx.doi.org/10.1016/j.otorri.2014.01.006 | DOI Listing |
Clin Case Rep
January 2025
Department of Medical Biochemistry, College of Health Sciences Dambi Dollo University Dambi Dollo Ethiopia.
A severe case of bilateral superior semicircular dehiscence was presented in Instituto de Neurorrehabilitación y Balance, Chile. The patient reports hearing and vestibular problems in certain situations; a complete analysis is carried out from the clinical history to neurological laboratory studies and imaging to diagnose bilateral semicircular canal dehiscence finally. Health condition management is under the ICF model, which will allow for determining and classifying the problems and possible interventions for this interesting clinical case.
View Article and Find Full Text PDFFront Neurol
December 2024
Department of Radiology, Clínica Universidad de Navarra, Madrid, Spain.
Introduction: The most common histopathological finding in Ménière's disease (MD) is endolymphatic hydrops (EH), which involves the dilation of the membranous labyrinth. The direct relationship between EH and MD is debated, although EH plays a crucial role in auditory and vestibular functional tests. MRI sequences such as 3D-FLAIR and 3D-real-IR are used to study EH, with the latter being more effective.
View Article and Find Full Text PDFJ Clin Med
November 2024
Department of Otorhinolaryngology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Multiple dehiscences of the otic capsule can exhibit behavior similar to Ménière's disease, not only from a clinical perspective but also in the results of audiovestibular tests. The main objective of this study is to characterize third mobile window etiologies from an audiovestibular perspective, while also evaluating the therapeutic response to four different treatment protocols. Furthermore, we aim to explore a potential association with the development of radiologically defined endolymphatic hydrops (EH).
View Article and Find Full Text PDFJ Vis Exp
November 2024
Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins University School of Medicine.
The living human inner ear is challenging to study because it is encased within dense otic capsule bone that limits access to biological tissue. Traditional temporal bone histopathology methods rely on lengthy, expensive decalcification protocols that take 9-10 months and reduce the types of tissue analysis possible due to RNA degradation. There is a critical need to develop methods to access fresh human inner ear tissue to better understand otologic diseases, such as Ménière's disease, at the cellular and molecular level.
View Article and Find Full Text PDFHNO
December 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Germany.
This article describes the surgical treatment of superior semicircular canal dehiscence syndrome (SCDS) by isolating the dehiscence using transmastoid two-point canal plugging while preserving the high-frequency vestibulo-ocular reflex (VOR) of the affected semicircular canal. The superior semicircular canal is opened via a transmastoid approach anterior (as far from the ampulla as possible) and posterior to the dehiscence and then plugged with connective tissue and bone dust. In two clinical exemplary cases, vestibular testing showed that the VOR measured by video head impulse (vHIT) test was preserved (patient 1: gain preoperative 0.
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