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Angiotensin-I converting enzyme (ACE) regulates the levels of disparate bioactive peptides, notably converting angiotensin-I to angiotensin-II and degrading amyloid beta. ACE is a heavily glycosylated dimer, containing 4 analogous catalytic sites, and exists in membrane bound and soluble (sACE) forms. ACE inhibition is a frontline, FDA-approved, therapy for cardiovascular diseases yet is associated with significant side effects, including higher rates of lung cancer.
View Article and Find Full Text PDFExploring Literacy and Knowledge Gaps and Disparities in Genetics and Oncogenomics Among Cancer Patients and the General Population: A Scoping Review.
Healthcare (Basel)
January 2025
Centre for Research and Technology Hellas, Institute of Applied Biosciences, 57001 Thessaloniki, Greece.
Background: Genetic and genomic literacy is pivotal in empowering cancer patients and citizens to navigate the complexities of omics sciences, resolve misconceptions surrounding clinical research and genetic/genomic testing, and make informed decisions about their health. In a fast-evolving scenario where routine testing has become widespread in healthcare, this scoping review sought to pinpoint existing gaps in literacy and understanding among cancer patients and the general public regarding genetics and genomics.
Methods: Adhering to the PRISMA framework, the review included 43 studies published between January 2018 and June 2024, which evaluated the understanding of genetics and genomics among cancer patients, caregivers, and citizens.
Vertical Gradient of Nitryl Chloride and Implications for Atmospheric Photochemistry in Pearl River Delta, China, during Wintertime.
Environ Sci Technol
January 2025
Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China.
Nitryl chloride (ClNO) is a key precursor of chlorine radicals, influencing atmospheric oxidation and secondary pollutants formation. Few studies have examined the ClNO chemistry from the perspective of the planetary boundary layer. Here, we conducted a vertically resolved investigation of ClNO at six heights (ranging from 5 to 335 m) on a 356 m tower in the Pearl River Delta, China, during winter 2021.
View Article and Find Full Text PDFRefinement of a meaning-centered counseling program for Chinese patients with advanced cancer: integrating cultural adaptation and implementation science approaches.
BMC Health Serv Res
January 2025
Department of Psychiatry, Weill Cornell Medicine, New York, NY, USA.
Background: This mixed methods study identified needed refinements to a telehealth-delivered cultural and linguistic adaptation of Meaning-Centered Psychotherapy for Chinese patients with advanced cancer (MCP-Ch) to enhance acceptability, comprehensibility, and implementation of the intervention in usual care settings, guided by the Ecological Validity Model (EVM) and the Practical, Robust Implementation and Sustainability Model (PRISM).
Methods: Fifteen purposively sampled mental health professionals who work with Chinese cancer patients completed surveys providing Likert-scale ratings on acceptability and comprehensibility of MCP-Ch content (guided by the EVM) and pre-implementation factors (guided by PRISM), followed by semi-structured interviews. Survey data were descriptively summarized and linked to qualitative interview data.
Localizing and Tailoring the Debriefing Assessment for Simulation in Healthcare to Optimize Fit.
Cureus
December 2024
SimTiki Simulation Center, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, USA.
Introduction Debriefing in healthcare simulation is helpful in reinforcing learning objectives, closing performance gaps, and improving future practice and patient care. The Debriefing Assessment for Simulation in Healthcare (DASH) is a validated tool. However, localized rater training for the DASH has not been described.
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