Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Objective: To determine outcome of dogs with a diagnosis of soft tissue sarcoma managed in first opinion practice.
Study Design: Retrospective, case-controlled study
Animals: Dogs (n = 350) with primary occurrence of a soft tissue sarcoma.
Methods: A previously validated questionnaire was sent to all veterinarians requesting clinical information and ultimate outcome for all dogs. Histologic sections were reviewed by a single pathologist.
Results: Most surgeries were unplanned, with only 15 (4%) dogs having a histologic and 59 (16.8%) dogs having a cytologic diagnosis before surgery. Median survival time for all dogs was not reached with 70% proportional survival at 5 years. Local recurrence developed in 73 (20.8%) cases. The extent of resection performed was not associated with improved survival (P = .2) or tumor recurrence (P = .8). Age <8 years (χ(2) = 6.1; P = .01), tumors <5 cm in size (χ(2) = 9.6; P = .002) and discrete tumors (χ(2) = 16.6; P < .001) had improved survival outcomes. On multivariate analysis, a high tumor grade was significant for recurrence (HR 5.8; P < .001; 95% CI: 2.2-14.8). Evidence of a selection bias towards less aggressive tumors being managed in first opinion practice was confirmed.
Conclusions: Wide resection margins are not the primary determinant of outcome for all soft tissue sarcoma. Veterinarians need to better understand the biologic behavior of a suspected soft tissue sarcoma before treatment to allow surgical margins to be adjusted accordingly.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/j.1532-950X.2014.12185.x | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!