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Canine soft tissue sarcoma managed in first opinion practice: outcome in 350 cases. | LitMetric

Canine soft tissue sarcoma managed in first opinion practice: outcome in 350 cases.

Vet Surg

Massey University Veterinary Teaching Hospital, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.

Published: October 2014

Objective: To determine outcome of dogs with a diagnosis of soft tissue sarcoma managed in first opinion practice.

Study Design: Retrospective, case-controlled study

Animals: Dogs (n = 350) with primary occurrence of a soft tissue sarcoma.

Methods: A previously validated questionnaire was sent to all veterinarians requesting clinical information and ultimate outcome for all dogs. Histologic sections were reviewed by a single pathologist.

Results: Most surgeries were unplanned, with only 15 (4%) dogs having a histologic and 59 (16.8%) dogs having a cytologic diagnosis before surgery. Median survival time for all dogs was not reached with 70% proportional survival at 5 years. Local recurrence developed in 73 (20.8%) cases. The extent of resection performed was not associated with improved survival (P = .2) or tumor recurrence (P = .8). Age <8 years (χ(2)  = 6.1; P = .01), tumors <5 cm in size (χ(2)  = 9.6; P = .002) and discrete tumors (χ(2)  = 16.6; P < .001) had improved survival outcomes. On multivariate analysis, a high tumor grade was significant for recurrence (HR 5.8; P < .001; 95% CI: 2.2-14.8). Evidence of a selection bias towards less aggressive tumors being managed in first opinion practice was confirmed.

Conclusions: Wide resection margins are not the primary determinant of outcome for all soft tissue sarcoma. Veterinarians need to better understand the biologic behavior of a suspected soft tissue sarcoma before treatment to allow surgical margins to be adjusted accordingly.

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Source
http://dx.doi.org/10.1111/j.1532-950X.2014.12185.xDOI Listing

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