AI Article Synopsis
- The 500 kDa protein plectin plays a crucial role in maintaining the structure of the cytoskeleton in mammalian cells and is found to be increased in certain cancers.
- Researchers have successfully mapped nearly all of the sequence-specific polypeptide backbone and resonance assignments for a 24 kDa segment of human plectin, specifically the C-terminal repeat domain 6.
- This study provides valuable insights into the molecular structure of plectin, which could enhance the understanding of its functions and implications in cancer.
Article Abstract
The 500 kDa protein plectin is essential for the cytoskeletal organization of most mammalian cells and it is up-regulated in some types of cancer. Here, we report nearly complete sequence-specific polypeptide backbone, (13)C(β) and methyl group resonance assignments for 24 kDa human plectin(4403-4606) containing the C-terminal plectin repeat domain 6.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194182 | PMC |
| http://dx.doi.org/10.1007/s12104-014-9559-x | DOI Listing |
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