AI Article Synopsis
- Genetic recombination is common among enteroviruses, but its patterns vary by species and types within those species.
- The study focused on Enterovirus C sub-group B, which includes strains like CVA-21 and CVA-24, examining their recombination patterns using specific viral sequences.
- Findings revealed multiple inter-typic recombination events primarily within sub-group B, suggesting that the occurrence of these events might depend on the evolutionary relationships among the strains.
Article Abstract
Genetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus). However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C) species contains 21 types. In the capsid coding P1 region, the types of EV-C species cluster further into three sub-groups (designated here as A-C). In this study, the recombination pattern of EV-C species sub-group B that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99 was determined using partial 5'UTR and VP1 sequences of enterovirus strains isolated during poliovirus surveillance and previously published complete genome sequences. Several inter-typic recombination events were detected. Furthermore, the analyses suggested that inter-typic recombination events have occurred mainly within the distinct sub-groups of EV-C species. Only sporadic recombination events between EV-C species sub-group B and other EV-C sub-groups were detected. In addition, strict recombination barriers were inferred for CVA-21 genotype C and CVA-24 variant strains. These results suggest that the frequency of inter-typic recombinations, even within species, may depend on the phylogenetic position of the given viruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983234 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094579 | PLOS |
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