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Characterization of two novel MCSFR paralogues in rainbow trout Oncorhynchus mykiss: New insights into the molecular mechanism underlying macrophage differentiation and modulation in fish.
Fish Shellfish Immunol
January 2025
Scottish Fish Immunology Research Centre, School of Biological Sciences, The University of Aberdeen, Aberdeen AB24 2TZ United Kingdom.
Article Synopsis
- The study investigates the colony-stimulating factor-1 receptor (MCSFR) in rainbow trout, identifying four gene variants, including two previously unrecognized, and explores their expression levels in various tissues.
- The protein structure of MCSFRs includes five immunoglobulin-like domains and suggests a conserved function across species.
- Following infection with Yersinia ruckeri, different MCSFR paralogues exhibit unique expression patterns, showing complex regulatory mechanisms influenced by various stimuli, enhancing the understanding of immune responses in fish.
The Putative Virulence Plasmid pYR4 of the Fish Pathogen Is Conjugative and Stabilized by a HigBA Toxin-Antitoxin System.
Biology (Basel)
August 2024
Antimicrobial Resistance, Omics and Microbiota Group, Department of Biosciences, Nottingham Trent University, Nottingham NG1 4FQ, UK.
The bacterium causes enteric redmouth disease in salmonids and hence has substantial economic implications for the farmed fish industry. The Norwegian outbreak isolate NVH_3758 carries a relatively uncharacterized plasmid, pYR4, which encodes both type 4 pili and a type 4 secretion system. In this study, we demonstrate that pYR4 does not impose a growth burden on the host bacterium, nor does the plasmid contribute to twitching motility (an indicator of type 4 pilus function) or virulence in a larval model of infection.
View Article and Find Full Text PDFBiomarkers of oxidative stress, biochemical changes, and the activity of lysosomal enzymes in the livers of rainbow trout ( Walbaum) vaccinated against yersiniosis before a challenge.
J Vet Res
September 2024
Department of Zoology, Institute of Biology, Pomeranian University in Słupsk, 76-200 Słupsk, Poland.
Introduction: This study aimed to evaluate biomarkers of oxidative stress (2-thiobarbituric acid reactive substances, aldehyde and ketone derivatives of oxidatively modified proteins and total antioxidant capacity), the activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase), that of lysosomal enzymes (alanyl aminopeptidase, leucyl aminopeptidase, β-N-acetylglucosaminidase and acid phosphatase) and changes in biochemical parameters (alanine aminotransferase, aspartate aminotransferase, de Ritis ratio, lactate dehydrogenase activity, lactate and pyruvate levels and their ratio) in the liver tissue of fish that were vaccinated against enteric redmouth disease and challenged with its causative agent, the bacterium .
Material And Methods: The vaccine was administered orally to trout, some of which were challenged with 61 days later. For comparison, unvaccinated and unchallenged trout and unvaccinated and challenged trout were also evaluated.
Innate and adaptive immune response of Rainbow trout (Oncorhynchus mykiss) naturally infected with Yersinia ruckeri.
Fish Shellfish Immunol
August 2024
Department of Biology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada. Electronic address:
Rainbow trout is an important fish species for Peruvian artisanal aquaculture, comprising over 60 % of the total aquaculture production. However, their industry has been highly affected by several bacterial agents such as Yersinia ruckeri. This pathogen is the causative agent of Enteric Redmouth Disease, and causes high mortality in fingerlings and chronic infection in adult rainbow trout.
View Article and Find Full Text PDFDuring October 2022, enteric redmouth disease (ERM) affected Chinese sturgeons at a farm in Hubei, China, causing mass mortality. Affected fish exhibited characteristic red mouth and intestinal inflammation. Investigation led to isolation of a prominent bacterial strain, zhx1, from the internal organs and intestines of affected fish.
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