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Proteomics analysis revealed the therapeutic role of adipose-derived mesenchymal stem cells on radiation-induced colorectal fibrosis in rats.
Biomed Pharmacother
December 2024
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:
Background: Radiation-induced colorectal fibrosis (RICF) is a chronic condition that can develop after pelvic radiation therapy for colorectal cancer. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as promising candidate for fibrosis treatment, yet the mode of action of ADSC upon RICF remains obscure. This study aimed to investigate the optimal delivery route, treatment timing, anti-fibrotic effects, and underlying mechanisms of ADSCs upon RICF.
View Article and Find Full Text PDFRelevance of oxidative stress for small intestinal injuries induced by nonsteroidal anti-inflammatory drugs: A multicenter prospective study.
Medicine (Baltimore)
December 2024
Department of Internal Medicine, Japanese Red Cross Himeji Hospital, Himeji, Japan.
Several reports revealed that oxidative stress was involved in the mouse model of nonsteroidal anti-inflammatory drug (NSAIDs)-induced small intestinal mucosal injuries. Thus, we aimed to investigate in the prospective clinical study, that the relevance of oxidative stress balance in small intestinal mucosal injury in NSAIDs users. We prospectively included 60 patients who had been taking NSAIDs continuously for more than 3 months and exhibited obscure gastrointestinal bleeding (number UMIN 000011775).
View Article and Find Full Text PDFClinicopathological features and prognosis of alpha-fetoprotein-producing colorectal adenocarcinoma.
Histopathology
December 2024
Department of Pathology, Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou.
Aims: Alpha-fetoprotein (AFP)-producing colorectal adenocarcinoma (AFPCRA) is uncommon, with obscure clinicopathological features and prognosis.
Methods And Results: In this retrospective comparison study on surgically resected colorectal adenocarcinomas (CRA, n = 2389), we investigated and compared clinicopathological and prognostic features between AFPCRA cases with elevated pre-operative serum AFP levels, as the AFPCRA study group (n = 49, 2.1%), and the exact sex-, age- and stage-matched CRA cases as the control group at a 1:2 ratio during the study period from 2011 to 2021.
Characteristics and prognosis of small bowel tumors: A retrospective study.
World J Clin Cases
December 2024
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Background: Small bowel tumors (SBTs) are a heterogeneous group of difficult-to-diagnose tumors that account for 2%-5% of all gastrointestinal tumors. Single-balloon enteroscopy greatly enhances the diagnosis and treatment of SBTs. However, few epidemiological studies have been conducted in Taiwan to determine the clinical profile of SBTs.
View Article and Find Full Text PDFMIR210HG Accelerates the Progression of Colorectal Cancer and Affects the Function of Colorectal Cancer Cells by Downregulating miR-1226-3p.
Turk J Gastroenterol
November 2024
Department of Gastrointestinal Tumor Surgery, Xingtai People's Hospital, Xingtai, China.
Background/aims: Colorectal cancer (CRC) is a widespread cancerous disease with an unfavorable prognosis. MIR210HG appears to have a significant connection with the development of CRC, but the precise regulatory mechanism remains obscure.
Materials And Methods: Quantitative real-time polymerase chain reaction was utilized to determine expression quantities of MIR210HG and miR-1226-3p.
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