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Ceftriaxone-resistant Neisseria gonorrhoeae detected in England, 2015-24: an observational analysis.
J Antimicrob Chemother
December 2024
Blood Safety, Hepatitis, STI & HIV Division, United Kingdom Health Security Agency, London, UK.
Objectives: Since June 2022, there has been a rise in the number of ceftriaxone-resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which a third were XDR. We describe the demographic and clinical details of the recent cases and investigate the phenotypic and molecular characteristics of the isolates. For a comprehensive overview, we also reviewed 16 ceftriaxone-resistant cases previously identified in England since December 2015 and performed a global genomic comparison of all publicly available ceftriaxone-resistant N.
View Article and Find Full Text PDFMycoplasma hominis as Cause of Extragenital Infection in Patients with Hypogammaglobulinemia: Report of 2 Cases and Literature Review.
Infect Dis Ther
October 2024
Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Mycoplasma hominis can be a part of human urogenital tract microbiome, and it is a frequent cause of urogenital infections. In rare cases, it can also cause extragenital infections, especially in immunocompromised patients. In this case series, we report two cases and provide a literature review of extragenital infections caused by M.
View Article and Find Full Text PDFDisseminated Gonococcal Infection Presenting as Isolated Septic Arthritis: A Case Report and Review of Literature.
Cureus
August 2024
Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Article Synopsis
- Gonorrhea is a gram-negative bacterium that spreads through sexual contact and can sometimes cause serious health issues, like disseminated gonococcal infection (DGI), when it spreads from the initial infection site.
- A case report details an 18-year-old diagnosed with septic arthritis in their hand, who had gonococcal bacteremia but no typical symptoms or mucosal involvement.
- This case emphasizes the need for doctors to recognize unusual symptoms of DGI, especially in patients with risky sexual behaviors, to facilitate early diagnosis and treatment, ultimately avoiding severe complications.
Early Research on Gonorrhea: Modern Implications for Asymptomatic Urethral, Extragenital, and Disseminated Gonococcal Infections.
Sex Transm Dis
September 2024
From the Center for AIDS and STD and the Department of Medicine, University of Washington, Seattle, WA.
Standardised protocol for a prospective international multicentre clinical-based evaluation of point-of-care tests for the screening of genital and extragenital chlamydial and gonococcal infections in men who have sex with men and for the screening of genital chlamydial, gonococcal and infections in at risk women.
BMJ Open
June 2024
Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Article Synopsis
- In 2016, the WHO reported approximately 374 million new infections from four curable STIs: chlamydia, gonorrhoea, syphilis, and trichomoniasis, highlighting the need for effective screening methods.
- Recent advancements in point-of-care tests (POCTs) for these STIs show promising results in lab studies, but there is a lack of clinical performance data, particularly among high-risk groups like men who have sex with men (MSM) and women.
- This research aims to evaluate the effectiveness and user acceptability of molecular-based diagnostic tests (Xpert CT/NG and Xpert TV) for detecting these infections in MSM and women across seven countries, comparing results to established reference tests.
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