Research on neighborhood effects has focused largely on residential neighborhoods, but people are exposed to many other places in the course of their daily lives-at school, at work, when shopping, and so on. Thus, studies of residential neighborhoods consider only a subset of the social-spatial environment affecting individuals. In this article, we examine the characteristics of adults' "activity spaces"-spaces defined by locations that individuals visit regularly-in Los Angeles County, California. Using geographic information system (GIS) methods, we define activity spaces in two ways and estimate their socioeconomic characteristics. Our research has two goals. First, we determine whether residential neighborhoods represent the social conditions to which adults are exposed in the course of their regular activities. Second, we evaluate whether particular groups are exposed to a broader or narrower range of social contexts in the course of their daily activities. We find that activity spaces are substantially more heterogeneous in terms of key social characteristics, compared to residential neighborhoods. However, the characteristics of both home neighborhoods and activity spaces are closely associated with individual characteristics. Our results suggest that most people experience substantial segregation across the range of spaces in their daily lives, not just at home.
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http://dx.doi.org/10.1007/s13524-014-0283-z | DOI Listing |
Brief Bioinform
November 2024
School of Computer Science and Technology, Harbin Institute of Technology, HIT Campus, Shenzhen University Town, Nanshan District, Shenzhen 518055, Guangdong, China.
Antimicrobial peptides (AMPs) emerge as a type of promising therapeutic compounds that exhibit broad spectrum antimicrobial activity with high specificity and good tolerability. Natural AMPs usually need further rational design for improving antimicrobial activity and decreasing toxicity to human cells. Although several algorithms have been developed to optimize AMPs with desired properties, they explored the variations of AMPs in a discrete amino acid sequence space, usually suffering from low efficiency, lack diversity, and local optimum.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
January 2025
Alzheimer's Drug Discovery Foundation, New York, NY, USA. Electronic address:
There is growing consensus in the Alzheimer's community that combination therapy will be needed to maximize therapeutic benefits through the course of the disease. However, combination therapy raises complex questions and decisions for study sponsors, from preclinical research through clinical trial design to regulatory, statistical, and operational considerations. In January 2024, the Alzheimer's Drug Discovery Foundation convened an expert advisory board to discuss the key considerations in each of these areas.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
School of Materials Science and Engineering, Hefei University of Technology, Hefei 230009 China; Key Laboratory of Advanced Functional Materials and Devices of Anhui Province, Hefei University of Technology, Hefei 230009 China; China International S&T Cooperation Base for Advanced Energy and Environmental Materials & Anhui Provincial International S&T Cooperation Base for Advanced Energy Materials, Hefei University of Technology, Hefei 230009, China. Electronic address:
NbO has become a focus of research for its suitability as an anode material in sodium ion capacitors (SICs), due to its open ionic channels. The integration of NbO with reduced graphene oxide (rGO) is known to boost its electrical conductivity. However, the sluggish interfacial charge transfer kinetics and interface collapse of NbO/rGO pose challenges to its rate capability and durability.
View Article and Find Full Text PDFClin Oral Investig
January 2025
Department of Behavioral and Community Dentistry, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, P.O. Box 450, Gothenburg, SE-40530, Sweden.
Objective: To investigate if changes in body mass index (BMI) result in changes of the mandibular trabecular bone structure.
Materials And Methods: Females (18-35 years at baseline, mean BMI 42,3) were followed from before (n = 117) until two years (n = 66) after obesity treatment (medical or surgical). The mandibular bone trabeculation was classified as sparse, dense, or mixed on intraoral radiographs (Lindh's index).
Sci Rep
January 2025
Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital Research Institute, F508 - 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
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