AI Article Synopsis
- The study aimed to assess how common herbs (Nigella sativa, Lepidium sativum, Trigonella foenum-graecum) influence the pharmacokinetics of sildenafil in beagle dogs.
- The research involved administering 100 mg of sildenafil to dogs, followed by herb treatments and blood sample analysis using HPLC to measure drug levels.
- Results showed that Nigella sativa significantly decreased sildenafil levels, while Lepidium sativum and Trigonella foenum-graecum also reduced drug concentration, suggesting that using these herbs with sildenafil could lower its effectiveness.
Article Abstract
The present study was conducted to investigate the effects of some commonly used herbs namely Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on the pharmacokinetics of sildenafil in beagle dogs. The study design involved four treatments in a non-balanced crossover design. Sildenafil was given one tablet 100 mg orally to each dog and blood samples were obtained. After a suitable washout period, animals were commenced on a specific herb treatment for 1 week. Blood samples were withdrawn at different time intervals and sildenafil was analyzed by HPLC method. Oral administration of Nigella sativa resulted in reduction of AUC0-∞, C max and t 1/2 as compared to the control. Treatment of Lepidium sativum resulted in a significant reduction in the C max and AUC. There were no significant differences between the rests of the pharmacokinetic parameters relative to those of the control. For Trigonella foenum-graecum, the effects were similar to those obtained in case of Lepidium sativum. It was concluded that concurrent use of investigated herbs alters the pharmacokinetics of sildenafil. Co-administration of investigated herbs should be cautious since their concomitant use might result in decrease in sildenafil bioavailability.
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| http://dx.doi.org/10.1007/s13318-014-0199-4 | DOI Listing |
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