We report a technique for blood flow detection using split spectrum Doppler optical coherence tomography (ssDOCT) that shows improved sensitivity over existing Doppler OCT methods. In ssDOCT, the Doppler signal is averaged over multiple sub-bands of the interferogram, increasing the SNR of the Doppler signal. We explore the parameterization of this technique in terms of number of sub-band windows, width and overlap of the windows, and their effect on the Doppler signal to noise in a flow phantom. Compared to conventional DOCT, ssDOCT processing has increased flow sensitivity. We demonstrate the effectiveness of ssDOCT in-vivo for intravascular flow detection within a porcine carotid artery and for microvascular vessel detection in human pulmonary imaging, using rotary catheter probes. To our knowledge, this is the first report of visualizing in-vivo Doppler flow patterns adjacent to stent struts in the carotid artery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1364/OE.22.007399 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhanced FFT-Root-MUSIC Algorithm Based on Signal Reconstruction via CEEMD-SVD for Joint Range and Velocity Estimation for FMCW Radar.
Sensors (Basel)
December 2024
Key Laboratory of Science and Technology on Micro-System, Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences, Shanghai 200050, China.
Frequency-modulated continuous-wave (FMCW) radar is used to extract range and velocity information from the beat signal. However, the traditional joint range-velocity estimation algorithms often experience significant performances degradation under low signal-to-noise ratio (SNR) conditions. To address this issue, this paper proposes a novel approach utilizing the complementary ensemble empirical mode decomposition (CEEMD) combined with singular value decomposition (SVD) to reconstruct the beat signal prior to applying the FFT-Root-MUSIC algorithm for joint range and velocity estimation.
View Article and Find Full Text PDFAims: ultrasound (US) diagnosis of enthesitis is burdened of low specificity, especially when it is performed in patients with psoriasis (PsO) but without clinical psoriatic arthritis (PsA), because of mechanical, dysmetabolic and age-related concurrent enthesopatic changes. We propose a novel US score to quantify the cortical-entheseal bone remodeling burden of several peripheral entheses, aiming to improve the specificity of US for PsA-related enthesitis, and to evaluate its diagnostic value in PsO patients with subsequent diagnosis of psoriatic arthritis (PsO/PsA).
Methods: clinical and US data of 119 consecutive patients with moderate/severe PsO and nonspecific musculoskeletal symptoms, were included in this retrospective study.
Joint suppression method for range-Doppler ambiguity sidelobes in DTMB-based passive bistatic radar.
Sci Rep
January 2025
The 705 Research Institute, China State Shipbuilding Corporation Limited, Xi'an, 710077, China.
To mitigate the impact of the suboptimal ambiguity function of digital television terrestrial multimedia broadcasting (DTMB) signal, used as the illuminator of opportunity in passive bistatic radar, this paper provides a detailed analysis of the ambiguity function characteristics based on the physical structure of the DTMB signal frame. It elucidates the mechanisms behind intra-frame and inter-frame range sidelobes, as well as Doppler sidelobes. Building on this analysis, a novel joint method for suppressing range-Doppler ambiguity sidelobes is proposed to achieve unambiguous target detection.
View Article and Find Full Text PDFBRISC-Mediated PPM1B-K63 Deubiquitination and Subsequent TGF-β Pathway Activation Promote High-Fat/High-Sucrose Diet-Induced Arterial Stiffness.
Circ Res
January 2025
Experimental Research Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, China (H.J.).
Background: Metabolic syndrome heightens cardiovascular disease risk primarily through increased arterial stiffness. We previously demonstrated the involvement of YAP (Yes-associated protein) in high-fat/high-sucrose diet (HFHSD)-induced arterial stiffness via modulation of PPM1B (protein phosphatase Mg/Mn-dependent 1B)-lysine63 (K63) deubiquitination. In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness.
View Article and Find Full Text PDFSynovitis scoring in hand osteoarthritis with ultrasonography: the performance of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) is comparable to synovial thickening alone.
RMD Open
December 2024
Rheumatology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands.
Background: Inflammation is increasingly recognised as a treatment target in hand osteoarthritis, and therefore correct measurement of local inflammation is essential. This study aimed to assess ultrasound scoring of synovitis and the additional value of the Global OMERACT/EULAR Ultrasound Synovitis Score (GLOESS) in hand osteoarthritis.
Methods: Data from the randomised, double-blinded Hand Osteoarthritis Prednisolone Efficacy (HOPE) trial were used.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!