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IL36RN Mutations and Correlated Characteristics in Generalized Pustular Psoriasis Patients in Can Tho City, Vietnam: A Cross-Sectional Study.
Dermatology
December 2024
Department of Dermato-Venereology, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
Article Synopsis
- Pustular psoriasis is a severe form of psoriasis marked by pustules on red skin, with generalized cases being life-threatening; this study focuses on the genetic mutations (specifically IL36RN) related to the disease in Vietnam.* -
- Conducted at Can Tho Dermatology Hospital, the research involved 59 patients and revealed that a significant number had previous psoriasis; the most common IL36RN mutation found was p.Arg10ArgfsX1, present in nearly half the participants.* -
- The study concluded that IL36RN mutations are prevalent among Vietnamese patients with pustular psoriasis and are linked to symptoms like fever and geographic tongue, suggesting important implications for treatment and understanding of the disease.*
A case of revertant mosaic-like normal-looking spots in a patient with erythroderma with IL36RN and CARD14 heterozygous mutations.
J Dermatol
December 2024
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- An 89-year-old woman from Japan had a skin condition that made her skin very red and scaly.
- Doctors found some unusual changes in her skin cells and discovered she had mutations in two specific genes (IL36RN and CARD14).
- She later developed small, round spots on her skin that looked normal, but tests showed these spots might be different from her red, scaly skin despite having the same gene mutations.
Clinical Characteristics and Disease Burden of Patients with Moderate-to-Severe Generalized Pustular Psoriasis Flares in Taiwan.
Dermatol Ther (Heidelb)
August 2024
Department of Dermatology, Drug Hypersensitivity, Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei and Keelung, No. 5, Fuxing St, Guishan District, Taoyuan, 333, Taiwan.
Article Synopsis
- * A retrospective analysis included 34 adult patients with 81 moderate-to-severe GPP flares between 2008 and 2021, revealing a high prevalence of IL36RN mutations (71.4%) in those tested and various systemic treatments being employed.
- * Complications like arthritis and skin infections were common post-flare, but no fatalities occurred; factors like prior smoking and existing hepatic disease were linked to increased GPP flare rates according to multivariate analysis.
Erythema multiforme after initiating spesolimab in a patient with generalized pustular psoriasis with IL36RN mutation.
Eur J Dermatol
June 2024
Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
TNFRSF11A variants contribute to systemic autoinflammatory diseases: A case series of 12 patients.
Semin Arthritis Rheum
October 2024
Joint Academic Rheumatology Program, First Department of Propaedeutic and Internal Medicine, National and Kapodistrian University of Athens, Greece. Electronic address:
Background: Limited evidence suggests that variants in TNFRSF11A gene, encoding RANK, may contribute to systemic autoinflammatory disease (SAID).
Aim/methods: To estimate the prevalence of TNFRSF11A variants in a cohort of patients with SAIDs screened for 26 related genes and describe the disease phenotypic expression.
Results: A total of 12 out of 167 patients, 7 males, aged (median) 38 years at disease onset, yielded at least one TNFRSF11A rare variant.
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