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Trends in Proton Pump Inhibitor Use in Sweden by Sex and Age: A Drug Utilisation Study.
Drug Saf
December 2024
Department of Women's and Children's Health, Karolinska Institutet, Tomtebodavägen 18A, 17177, Stockholm, Sweden.
Background: Proton pump inhibitors (PPIs) are among the most popular drugs worldwide. Yet, there are concerns on long-term safety and poor adherence to prescription guidelines. Off-label use in children and increasing maintenance use in older adults may be particularly worrisome.
View Article and Find Full Text PDFExploring the Therapeutic Potential of Green-Synthesized Gold Nanoparticles and Extract for Inflammatory Bowel Disease.
Antioxidants (Basel)
July 2024
Departamento de Morfologia, Faculdade de Medicina, Centro de Ciências da Saúde, Universidade Federal do Ceará, Fortaleza 60440-900, Brazil.
Addressing disease remission and treatment adherence in inflammatory bowel diseases (IBDs), such as Crohn's disease, poses significant challenges due to underlying oxidative and inflammatory processes. Nanotechnology emerges as a promising avenue for enhancing therapeutic outcomes in IBD by optimizing drug bioactivity, reducing toxicity, and extending circulation time. Gold nanoparticles, known for their resistance to gastrointestinal pH and possessing antioxidant and anti-inflammatory properties, offer particular promise.
View Article and Find Full Text PDFIpomoea carnea mitigates ethanol-induced ulcers in irradiated rats via Nrf2/HO pathway: an in vivo and in silico study.
Sci Rep
February 2024
Health Radiation Research Department, National Center for Radiation Research and Technology, (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
The aim of this study was to investigate the potential of Ipomoea carnea flower methanolic extract (ICME) as a natural gastroprotective therapy against ethanol-induced gastric ulcers, particularly in individuals exposed to ionizing radiation (IR). The study focused on the Nrf2/HO signaling pathway, which plays a crucial role in protecting the gastrointestinal mucosa from oxidative stress and inflammation. Male Wistar rats were divided into nine groups, the control group received distilled water orally for one week, while other groups were treated with ethanol to induce stomach ulcers, IR exposure, omeprazole, and different doses of ICME in combination with ethanol and/or IR.
View Article and Find Full Text PDFComprehensive pharmacological geriatric assessment compared to usual care in an older adult with cancer in the absence of polypharmacy.
J Oncol Pharm Pract
October 2023
Department of Medical Oncology, University Hospital Waterford, Waterford, Ireland.
Introduction: Medication reconciliation as part of a Comprehensive Geriatric Assessment by a specialist pharmacist is a process that has been shown to be beneficial in terms of medication adherence in patients taking oral anticancer medication and potentially cost-effective in cancer patients. Medication review guidelines in older adults with cancer suggest using polypharmacy (≥ 5 medications) as an indication for medication review in older adults with cancer.
Case Report: We present a case where a medication review as part of a Comprehensive Geriatric Assessment in the absence of polypharmacy resulted in two pharmacist interventions when standard care resulted in no intervention.
Synergistic Effect of Polysaccharides from Chamomile Tea with Nitazoxanide Increases Treatment Efficacy against .
Life (Basel)
December 2022
EVAHPI-Extracellular Vesicles and Host-Parasite Interactions Research Group, Laboratório de Biologia Molecular e Sistemática de Tripanossomatideos, Carlos Chagas Institute-Fiocruz, Curitiba 81310-020, PR, Brazil.
(syn. ) is a protozoa parasite that produces one of the most frequent waterborne causes of diarrhea worldwide. This protozoan infects most mammals, including humans, and colonizes the small intestine, adhering to intestinal cells.
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