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Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux. | LitMetric

Sleep disorders and the prevalence of asymptomatic nocturnal acid and non-acid reflux.

Ann Gastroenterol

Division Gastroenterology and Hepatology (Christine Herdman, Dina Halegoua-De Marzio, Susie Denuna-Rivera, Sidney Cohen, Anthony J. DiMarino), Thomas Jefferson University, Philadelphia, PA, USA.

Published: January 2013

AI Article Synopsis

Article Abstract

Background: Nocturnal acid reflux is associated with symptomatic and asymptomatic sleep arousals, leading to fragmented sleep. The frequency and influence of acid reflux in patients with various forms of insomnia has not been reported. The aim of this study was to quantify nocturnal acid and nonacid reflux in patients with primary sleep disorders as previously diagnosed by polysomnography.

Methods: THIRTY ONE SUBJECTS WERE STUDIED: (A) 9 subjects with a polysomnographically diagnosed sleep disorder (1 with restless legs syndrome, 4 with narcolepsy, 4 with periodic limb movement disorder); (B) 12 subjects with primary insomnia (PI) and unrevealing polysomnography; and (C) 10 controls without disturbed sleep. All subjects underwent a physical examination and 24 h transnasal pH and impedance monitoring to detect acid and non-acid reflux.

Results: The 21 subjects with fragmented sleep due to a primary sleep disorder had significantly more recumbent acid exposure (>1.2% of time) as compared with control subjects (33% versus 0%). When fragmented sleep subjects were divided into two groups, 17% of PI subjects and 55% of subjects with a diagnosed sleep disorder had significant recumbent acid exposure (P=0.009). Likewise, the median recumbent nonacid events were increased in the sleep disordered group (P=0.011).

Conclusions: This study indicates that patients with primary sleep disorders have prominent nocturnal acid reflux without symptoms of daytime acid reflux. Acid reflux is most prominent in patients with polysomnographic findings of disturbed sleep as compared to patients with PI; while non acid reflux is increased minimally in these patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959439PMC

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