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Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats.
Biomed Pharmacother
August 2021
Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, INSERM U1050, Paris F-75231 France; Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Paris F-75231 France. Electronic address:
In the brain, aminopeptidase A (APA) generates angiotensin III, one of the effector peptides of the brain renin-angiotensin system (RAS), exerting tonic stimulatory control over blood pressure (BP) in hypertensive rats. Oral administration of firibastat, an APA inhibitor prodrug, in hypertensive rats, inhibits brain APA activity, blocks brain angiotensin III formation and decreases BP. In this study, we evaluated the efficacy of firibastat in combination with enalapril, an angiotensin I-converting enzyme inhibitor, and hydrochlorothiazide (HCTZ), in conscious hypertensive deoxycorticosterone acetate (DOCA)-salt rats, which display high plasma arginine-vasopressin levels, low circulating renin levels and resistance to treatment by systemic RAS blockers.
View Article and Find Full Text PDFHemostatic bitherapy for spurting bleeding.
Ann Gastroenterol
January 2012
1 Department of Internal Medicine & Hepato-Gastroenterology Unit, University Hospital of Ioannina, Greece.
Peptic upper gastrointestinal bleeding: diagnosis and treatment. A monocentric experience on a 5 years period.
Rom J Intern Med
March 2011
Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Timişoara, Romania.
Aim: We evaluated all the cases of upper gastrointestinal hemorrhages admitted in the Department of Endoscopy of our Clinic during a 5 years period.
Material And Method: 810 patients were included in our study, 64.3% males and 36.
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