Falsely elevated serum or plasma potassium level can be the result of mechanical injury to blood cells. We describe pseudohyperkalaemia caused by pneumatic tube transport of blood specimens from a patient with leukaemia. Clinicians should be aware of this possibility when interpreting the clinical significance of hyperkalaemia. In leukaemic patients, pneumatic tube transport of blood specimens for potassium analysis should be avoided.

Download full-text PDF

Source
http://dx.doi.org/10.12809/hkmj133881DOI Listing

Publication Analysis

Top Keywords

pneumatic tube
12
tube transport
12
transport blood
12
blood specimens
12
pseudohyperkalaemia acute
4
acute leukaemia
4
leukaemia association
4
association pneumatic
4
blood
4
specimens falsely
4

Similar Publications

In hospitals, IV bags can be prepared in advance for logistical and microbial safety reasons in a compounding unit and then transported to wards. Transport of protein drugs using a pneumatic tube system has been reported to result in high particle levels. In this study, pneumatic tube transport of trastuzumab in saline polyolefin bags was compared to delivery by hospital porters using an electric platform truck in an underground tunnel system.

View Article and Find Full Text PDF

Quantitative sizing of microplastics up to 20 µm using ICP-TOFMS.

J Anal At Spectrom

January 2025

ETH Zurich, Department of Chemistry and Applied Biosciences Vladimir-Prelog-Weg 1 8093 Zurich Switzerland

A fundamental study of four different sample introduction systems was carried out to evaluate the upper size limit of microplastics measured by inductively coupled plasma-time-of-flight-mass spectrometry (ICP-TOFMS). Three different, certified microplastic samples (PS, PMMA and PVC) within a size range of 3-20 µm in suspension were measured. In this study, no particles larger than 10 µm could be detected using pneumatic nebulization for sample introduction.

View Article and Find Full Text PDF

Impact of pneumatic tube transportation on the aggregation of monoclonal antibodies in clinical practice.

Eur J Pharm Sci

January 2025

Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Biopharmaceutical Technology, TUM School of Life Sciences, Technical University of Munich, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address:

Postproduction handling and in-hospital transportation of antibody drugs cause mechanical stress, including interfacial and shear stress, that can induce antibody unfolding and aggregation. The handling practices differ significantly between hospitals and the impact on protein stability is unknown. For example, the mechanical stress caused by transport via pneumatic tube systems (PTS) on therapeutic antibody aggregation is a potential safety and quality gap.

View Article and Find Full Text PDF

Manual flagging failed to identify pseudohyperkalemia in acute myeloid leukemia: case report.

Int J Emerg Med

October 2024

Division of Nephrology, Department of Internal Medicine, UCSF Fresno Center for Medical Education and Research, 155 N Fresno St, Fresno, CA, 93701, USA.

Article Synopsis
  • Pseudohyperkalemia, often seen in chronic lymphocytic leukemia, is rare in acute myeloid leukemia (AML), but can pose diagnostic challenges, as shown in a case involving a 55-year-old man with severe leukocytosis and falsely elevated potassium levels.
  • Despite the lab's manual flagging system meant to identify such cases, it failed to function properly, leading to reliance on clinicians' instincts for the correct diagnosis of pseudohyperkalemia.
  • The incident was linked to pneumatic tube transport of blood samples, prompting the lab to consider enhancements in its flagging system and the importance of using whole blood for potassium measurements in cases of significant leukocytosis.
View Article and Find Full Text PDF
Article Synopsis
  • A 58-year-old woman experienced complications, including regurgitation and obstruction, after her SG and subsequent ring placement, necessitating a two-step endoscopic procedure with a new Luso-Cor esophageal stent for treatment.
  • After initial unsuccessful attempts to alleviate symptoms through dilatation, the stent was ultimately removed, revealing a partially eroded calibration ring, and the patient reported being asymptomatic afterward, leading to a conservative follow-up approach.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!