This article presents a case of Hurthle cell adenoma (HCA) of the thyroid gland with a review of literature on Hurthle cell tumors. This case presented is that of a 57-year-old woman with a recurrent thyroid swelling. She previously underwent a right hemithyroidectomy for thyroid mass 10 years prior. A left lobectomy was done and microscopic examination revealed a HCA of the thyroid. The patient was discharged on thyroid replacement therapy and has remained healthy after more than 24 months of follow-up. The literature review highlights the criteria for diagnosis, the role of imaging and fine needle aspiration cytology (FNAC) in preoperative diagnosis.
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http://dx.doi.org/10.4103/1119-3077.130249 | DOI Listing |
Pak J Med Sci
December 2024
Najmul Islam, MBBS, MRCP, FRCP. Professor, Endocrinology Diabetes and Metabolism, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
Objective: Although differentiated thyroid cancers have a good prognosis overall, their incidence is on the rise with extremely limited data available in our region. The objective was to describe the outcomes of differentiated thyroid carcinoma in a tertiary care hospital.
Methods: This was a retrospective study conducted at Aga Khan University Hospital.
Cancer Rep (Hoboken)
December 2024
Internal Medicine Department, Jordan University of Science and Technology, Irbid, Jordan.
Background: Hürthle cell (HCC) and columnar cell variants (CCV) are rare subtypes of thyroid cancer.
Aims: This study used machine learning (ML) to evaluate treatment effectiveness and develop prognostic models.
Methods: Chi-square tests, Kaplan-Meier curves, log-rank tests, and Cox regression were used.
Diagn Cytopathol
November 2024
Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, New York, USA.
Introduction: Indeterminate oncocytic/Hürthle cell lesions on thyroid cytology are reflexed to molecular testing. This study aims to examine the cytologic characteristics of thyroid fine-needle aspiration (FNA) smears with oncocytes classified as atypia of undetermined significance (AUS) with particular molecular patterns that can aid in determining a more conclusive Bethesda category upfront thus decreasing unnecessary testing and associated costs.
Materials And Methods: Our pathology database was searched for thyroid FNAs with AUS for oncocyte predominance from 2019 to 2022.
Am J Surg Pathol
January 2025
Department of Pathology, Institut of Pathologie Multisite, University Hospital of Lyon Sud, Hospices Civils de Lyon.
Oncocytic adenocarcinoma (OC) of the salivary glands is a rare and controversial entity. It was recently reclassified as "salivary carcinoma NOS and emerging entities" in the 2022 WHO classification of head and neck tumors. The lack of specific molecular alterations and its potential affiliation with other salivary gland carcinomas, such as the oncocytic mucoepidermoid carcinomas (OMEC) or the oncocytic subtype of salivary duct carcinomas (OSDC) justified this reclassification.
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