AI Article Synopsis
- The study looked at small, abnormal groups of B-cells found in bone marrow samples, which were incidentally identified during evaluation.
- Researchers focused on cases where these B-cell populations made up 5% or less of the total cells, with no previous history of lymphoma or other related conditions.
- Among 3,052 samples, only 41 showed these populations, with some featuring lymphoid aggregates, but none were diagnosed as lymphoma, although a few raised concerns for potential B-cell lymphoma.
Article Abstract
Objectives: Bone marrows (BMs) with incidentally identified, small monotypic B-cell populations (MBPs) were evaluated.
Methods: BM aspirates with MBPs representing 5% or less of total events by flow cytometry, less than 5.0 × 10(9)/L B cells in blood, and no history of lymphoma or MBP with a different phenotype from prior lymphoma were selected. Clinical, immunophenotypic, and histologic findings were evaluated.
Results: Forty-one of 3,052 BMs had MBPs at 5% or less of total events (median, 1%); 17 were females and 24 were males aged 30 to 87 years (median, 73 years). The MBPs were CD5- in 24, CD5+ resembling chronic lymphocytic leukemia (CLL) in 13, and CD5+ unlike CLL in four. Eighteen of 40 had lymphoid aggregates (LAs) with mostly T cells or a mixture of B and T cells, but three cases had B-cell-rich LAs.
Conclusions: Unlike monoclonal B lymphocytosis in blood, MBPs in BMs were more commonly CD5-. Forty-five percent of BMs had LAs; none were interpreted as lymphoma, although three were suspicious for B-cell lymphoma.
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| http://dx.doi.org/10.1309/AJCPD5TOBDJU4GKO | DOI Listing |
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