AI Article Synopsis
- The study aimed to explore the serum levels of B-cell activating factor (BAFF) in patients with polymyositis (PM) and dermatomyositis (DM), focusing on its relationship with disease activity.
- Conducted with 92 PM/DM patients and 25 healthy controls, the research found that BAFF levels were significantly higher in PM/DM patients, showing correlations with overall and muscle-specific disease activity.
- The results indicate that elevated serum BAFF levels may serve as a useful biomarker for tracking disease activity in patients with PM and DM.
Article Abstract
Aim: To investigate serum levels of B-cell activating factor (BAFF) in the patients with polymyositis (PM) and dermatomyositis (DM), and to systematically examine the association between serum BAFF levels and disease activity in PM/DM patients.
Patients & Methods: A cross-sectional analysis included 92 PM/DM patients and 25 healthy control subjects. A longitudinal study followed 24 patients. Serum BAFF concentrations were detected by the ELISA method.
Results: Serum BAFF levels in PM/DM patients were significantly higher than those in healthy controls. A cross-sectional assessment revealed a modest correlation between serum BAFF levels and global disease activity and a mild correlation between serum BAFF levels and muscle disease activity. The longitudinal study showed that serum BAFF levels modestly correlated with global disease activity and muscle disease activity.
Conclusion: Resulting data showed high serum BAFF levels in PM/DM patients and suggested BAFF as a serological biomarker for PM/DM disease activity.
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| http://dx.doi.org/10.2217/bmm.13.124 | DOI Listing |
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