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Relationship between the strength of biofilm production and the presence of and genes in isolated from skin and soft tissue infections.
Heliyon
December 2024
Molecular Microbiology Research Center, Faculty of Medicine, Shahed University, Tehran, Iran.
This research sought to investigate the association between the occurrence of the and genes and the strength of biofilm formation, as well as to assess the efficacy of vancomycin and ceftaroline against strains obtained from skin and soft tissue infections (SSTIs). A total of 134 isolates were collected from SSTI patients and identified through standard microbiological techniques. Vancomycin and ceftaroline susceptibility testing were performed using the agar dilution and disc diffusion methods, respectively.
View Article and Find Full Text PDFAntibacterial activity of withanolides, labdane glucosides, flavonoids and other constituents from two populations of Physalis patula.
Fitoterapia
January 2025
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Col. Juriquilla 76230, Querétaro, Qro., Mexico. Electronic address:
Two populations of Physalis patula Miller collected in different localities (Querétaro and Teotihuacán) of Central México were analyzed. Eight new compounds including three withanolides, physapatolides A-C (1-3), two labdanes, 12-epi-physacoztomatin (10) and physapatulone (12), besides three 12-O-glucosyl labdanes, patulosides A-C (13-15), were isolated from these collections. A series of known withanolides, flavonoids, labdanes, sucrose esters, and sterols were also isolated.
View Article and Find Full Text PDFPhenotypic and genotypic correlates of the sodium bicarbonate-responsive phenotype among methicillin-resistant Staphylococcus aureus isolates from skin and soft-tissue infections.
Clin Microbiol Infect
December 2024
Departments of Medicine and Medical Microbiology/Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Objectives: The objective of this study is to assess the frequency of the novel sodium bicarbonate (NaHCO)-responsive phenotype, wherein clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates are rendered susceptible to standard-of-care β-lactams in the presence of NaHCO, in a collection of 103 clinical U.S. MRSA skin and soft-tissue infection (SSTI) isolates and 22 clinical European SSTI isolates.
View Article and Find Full Text PDFReshaping the battlefield: A decade of clonal wars among Staphylococcus aureus in China.
Drug Resist Updat
January 2025
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Jinan Microecological Biomedicine Shandong Laboratory, Jinan, China; Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:
Background: Long-term comprehensive studies on the genomic epidemiology of both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) isolates are limited in China. Here, we aimed to assess the genomic epidemiological characteristics and population dynamics of S.
View Article and Find Full Text PDFBloodstream infections caused by Staphylococcus aureus in patients admitted to King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Eur Rev Med Pharmacol Sci
November 2024
Department of Clinical Microbiology Laboratory, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Objective: Currently, there is a limited amount of published data on the incidence of bloodstream infections (BSI) caused by both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA) in most parts of the Arabian Peninsula. Thus, it is extremely important to have information concerning the distribution and prevalence of MRSA and MSSA to better handle and manage future epidemics. This study aimed to investigate the correlation between MRSA and/or MSSA with BSI at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia.
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