[Changes of ocular aberration after wavefront-guided aspherical LASIK for myopia].

Objective: To compare the higher order aberration of wavefront-guided aspherical versus wavefront-guided and Q-value guided aspheric personalized LASIK surgery in the treatment of myopia.

Methods: Prospective study.120 patients with myopia and/or astigmatism(240 eyes) were involved in our hospital from August 2010 to December 2010. There was a prospective study, divided into three groups: Wavefront-guided aspherical personalized LASIK in group A; Wavefront-guided LASIK in group B; Q-value guided aspheric LASIK in group C. The follow-up time was 6 months. The comparison of data before and after operation was two independent samples t test. The comparison among three groups was one-way analysis of variance, and multiple comparison between groups was Dunnet t test.

Results: A group: The differences between before and after surgery were not statistically significant in higher order aberration (t1 week = 0.874, P1 week = 0.387; t1 month = -1.145, P1 month = 0.259; t3 month = 0.652, P3 month = 0.518; t 6 month = 0.496, P6 month = 0.439) , but as the extension of time, The values have a tendency to become smaller; the difference was not statistically significant in spherical aberration between before and after surgery 1 week (t = -1.815, P = 0.077), and was statistically significant between before and after surgery 1 month, 3 months and 6 months after surgery (t1 month = -4.410, P1 month = 0.000; t3 month = -2.375, P 3 month = 0.022; t6 month = -1.870, P 6 month = 0.000) , the values after surgery were higher. The differences between before and after surgery were not statistically significant in coma aberration (t1 week = 1.028, P 1 week = 0.310; t1 month = 0.847, P1 month = 0.402; t3 month = 0.210, P3 month = 0.984; t6 month = 0.533, P6 month = 0.597). At 6 months, the higher order aberration and spherical aberration in A group and C group were significantly lower than the B group, and the differences were statistically significant (P A&B = 0.000; PC&B = 0.000) , the differences between A group and C group were not statistically significant in higher order aberration and spherical aberration(P = 0.866), but A group is less than the C group in changes before and after surgery. The differences among three groups were not statistically significant in the vertical and horizontal coma (Fvertical coma = 0.367, Pvertical coma = 0.683; Fhorizontal coma = 0.254, Phorizontal coma = 0.797).

Conclusion: Wavefront-guided aspherical personalized LASIK compared with wavefront-guided personalized LASIK can better reduce the increases of the higher order aberration and spherical aberration, and the changes between preoperative and postoperative is less than Q-value guided aspheric personalized LASIK.