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Rapid on-site evaluation using telecytology: Quality assurance study at a high-volume cancer center.
Cancer Cytopathol
January 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background: Telecytology-assisted rapid on-site evaluation (ROSE) offers a cost-effective method to enhance minimally invasive biopsies like fine needle aspiration and core biopsies with touch preparation. By reducing nondiagnostic sampling and the need for repeat procedures, ROSE via telecytology facilitates prompt triage for ancillary tests, improving patient management. This study examines cases initially deemed adequate for diagnosis during telecytology-assisted ROSE but later categorized as nondiagnostic at final evaluation (NDIS).
View Article and Find Full Text PDFApplication of flow cytometry immunophenotypic analysis for the diagnosis of mature B-cell lymphomas/leukemias.
Hum Pathol
December 2024
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
Flow cytometry immunophenotyping (FCI) is an important and indispensable tool in the diagnosis of mature B-cell lymphomas/leukemias, particularly for small fine needle aspiration and needle core biopsy specimens which are becoming increasingly popular for diagnostic purposes. FCI has several advantages. Given its multiparametric nature, FCI can analyze the expression of multiple antigens simultaneously on the same cell of interest, qualitatively and quantitively.
View Article and Find Full Text PDFThe Impact and Wider Implications of Remote Consultations for General Practice in Norway: Qualitative Study Among Norwegian Contract General Practitioners.
JMIR Form Res
December 2024
General Practice Research Unit, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Background: The digital shift toward remote consultations in general practice needs ongoing monitoring to understand its impact on general practice organizations and the wider health care system.
Objective: This study aimed to explore how remote consultations impact on contracted general practitioner (GP) practices and how GPs perceive the implications of this uptake for the overall health care system.
Methods: In total, 5 focus groups were conducted with a total of 18 GPs from all 4 health regions of Norway in 2022.
Calibration curve for radiation dose estimation using FDXR gene expression biodosimetry - premises and pitfalls.
Int J Radiat Biol
August 2024
Cancer Mechanisms and Biomarkers Group, Centre for Radiation, Chemical and Environmental Hazards, UK Health Security Agency, Oxfordshire, England.
Purpose: Radiation-induced alterations in gene expression show great promise for dose reconstruction and for severity prediction of acute health effects. Among several genes explored as potential biomarkers, FDXR is widely used due to high upregulation in white blood cells following radiation exposure. Nonetheless, the absence of a standardized protocols for gene expression-based biodosimetry is a notable gap that warrants attention to enhance the accuracy, reproducibility and reliability.
View Article and Find Full Text PDFAnatomic Basis of Rectal Cancer Staging: Clarifying Controversies and Misconceptions.
Radiographics
July 2024
From the Departments of Abdominal Imaging (H.K.), Colon and Rectal Surgery (T.K.), and Anatomical Pathology (M.W.T.), University of Texas MD Anderson Cancer Center, PO Box 301402, Unit 1473, Houston, TX 77230-1402; Department of Radiology, Northwestern University, Chicago, Ill (H.G., C.L.V., L.C.K.); Department of Radiology, University of Texas Health Science Center, Houston, Tex (M.O.A.); Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pa (E.M.); Department of Radiology, Endeavor Health Medical Group, Evanston, Ill (M.M.); and Department of Radiological Sciences, University of California, Irvine, School of Medicine, Orange, Calif (S.L.).
Article Synopsis
- Rectal MRI offers a comprehensive view of pelvic anatomy, highlighting the tumor's relationship with essential structures like the mesorectal fascia and sphincter complex, which is crucial for treatment planning.
- However, there are notable challenges in accurately interpreting MRI results due to inconsistencies in defining the rectum, differentiating it from the anal canal and sigmoid colon, and understanding the location of surrounding anatomy.
- These interpretational difficulties can significantly affect treatment decisions, emphasizing MRI's role in guiding surgical resection and chemoradiotherapy for better management of rectal cancer.
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