AI Article Synopsis
- The article investigates the effects of methylene blue (MB) on esophageal burns induced by corrosive substances in a rat model.
- In a study involving 21 rats, three groups were tested: one control group with saline irrigation, one untreated group, and one group treated with MB following burns with a strong alkaline solution.
- Results showed that MB treatment improved antioxidant levels and reduced tissue damage, suggesting its potential protective effects against corrosive esophagitis.
Article Abstract
Introduction: The aim of the article is to investigate the beneficial effects of methylene blue (MB) on the acute phase of experimental corrosive esophageal burns.
Materials And Methods: A total of 21 male Sprague-Dawley rats were allocated into three groups with an equal number in each group. In Group 1 (control), the esophageal lumen was irrigated with saline. In Groups 2 (untreated) and 3 (MB treatment), the distal esophagus was burned with 30% NaOH solution. In Group 3, MB was applied locally on the distal esophageal lumen (30 mg/kg) 90 minutes after the burn. In all the groups, animals were humanely killed at the end of the 7th day. Distal esophageal specimens were obtained for histopathological and biochemical examinations.
Results: MB increased the tissue superoxide dismutase levels and the total antioxidant status, whereas it decreased the levels of the total oxidant status with significant attenuation of histopathological damage.
Conclusion: MB might have reduced the tissue damage in corrosive esophagitis because of its antioxidant effects.
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| http://dx.doi.org/10.1055/s-0034-1371715 | DOI Listing |
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