AI Article Synopsis
- TYK2 is a key nonreceptor tyrosine kinase involved in immune signaling and development.
- A crystal structure of TYK2 shows its interaction with an intracellular peptide from the interferon-α receptor (IFNAR1), highlighting an unexpected binding mode.
- This research is significant as it provides the first structural view of a JAK-receptor complex, revealing how JAKs adapt to interact with various receptors.
Article Abstract
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family of nonreceptor tyrosine kinases, which are essential for proper signaling in immune responses and development. Here we present a 2.0-Å-resolution crystal structure of a receptor-binding fragment of human TYK2, encompassing the FERM and SH2 domains, in complex with a so-called 'box2'-containing intracellular peptide motif from the interferon-α receptor chain 1 (IFNAR1). The TYK2-IFNAR1 interface reveals an unexpected receptor-binding mode that mimics a SH2 domain-phosphopeptide interaction, with a glutamate replacing the canonical phosphotyrosine residue. This structure provides the first view, to our knowledge, of a JAK in complex with its cognate receptor and defines the molecular logic through which JAKs have evolved to interact with divergent receptor sequences.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161281 | PMC |
| http://dx.doi.org/10.1038/nsmb.2807 | DOI Listing |
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