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On the origin of leukemic species. | LitMetric

On the origin of leukemic species.

Cell Stem Cell

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address:

Published: April 2014

AI Article Synopsis

Article Abstract

Recent studies (Shlush et al., 2014; Corces-Zimmerman et al., 2014) have demonstrated that leukemias develop from hematopoietic stem cells that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations leading to cancer. Preleukemic cells survive chemotherapy and serve as reservoirs for disease, generating new clones and leading to relapse.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2014.03.008DOI Listing

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