Blood clotting specifically supports the metastatic dissemination of malignant cells to the lung. We have recently demonstrated that 2 tumor types that are prone to form lung metastases, renal cell carcinoma and soft tissue sarcoma, share specific adhesive mechanisms that support the invasion and colonization of blood clots in the pulmonary vasculature.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961483 | PMC |
| http://dx.doi.org/10.4161/onci.27338 | DOI Listing |
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