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Drug Development.
Alzheimers Dement
December 2024
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala, India.
Background: Neuroinflammation plays an important role in progression of Alzheimer's disease (AD). Interlukin-6 (IL-6) is well identified marker in initiating and regulating inflammation, and formation of senile plaques in brain. Therefore, simultaneous inhibition of both IL-6 and acetylcholinesterase (AChE) may be an effective strategy for AD.
View Article and Find Full Text PDFProcess-based screening of porous materials for vacuum swing adsorption based on 1D classical density functional theory and PC-SAFT.
Mol Syst Des Eng
January 2025
Energy & Process Systems Engineering, Department of Mechanical and Process Engineering, ETH Zurich Zurich Switzerland
Adsorption-based processes are showing substantial potential for carbon capture. Due to the vast space of potential solid adsorbents and their influence on the process performance, the choice of the material is not trivial but requires systematic approaches. In particular, the material choice should be based on the performance of the resulting process.
View Article and Find Full Text PDFThe effect of environmental factors on transepithelial potential in a model Amazonian teleost, the tambaqui (Colossoma macropomum): Implications for sodium balance in harsh environments.
J Fish Biol
January 2025
Laboratory of Ecophysiology and Molecular Evolution, Brazilian National Institute for Research of the Amazon (INPA), Manaus, Brazil.
The tambaqui (Colossoma macropomum, G. Cuvier 1818) thrives both in the ion-poor waters of the Amazon and in commercial aquaculture. In both, environmental conditions can be harsh due to low ion levels, occasional high salt challenges (in aquaculture), low pH, extreme PO levels (hypoxia and hyperoxia), high PCO levels (hypercapnia), high ammonia levels (in aquaculture), and high and low temperatures.
View Article and Find Full Text PDF[Effect of extra corporeal reducing pre-load on pulmonary mechanical power in patients with acute respiratory distress syndrome].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2024
Department of Public Utilities Development, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, Henan, China.
Objective: To explore the effects of veno-venous extra corporeal carbon dioxide removal (V-V ECCOR) on local mechanical power and gas distribution in the lungs of patients with mild to moderate acute respiratory distress syndrome (ARDS) receiving non-invasive ventilation.
Methods: Retrospective research methods were conducted. Sixty patients with mild to moderate ARDS complicated with renal insufficiency who were transferred to the respiratory intensive care unit (RICU) through the 96195 platform critical care transport green channel from January 2018 to January 2020 at the collaborative hospitals of Henan Provincial People's Hospital were enrolled.
Role of Mesoporosity in Hard Carbon Anodes for High-Energy and Stable Potassium-Ion Storage.
Small
January 2025
Department of Material Science Engineering, Gachon University, Seongnamdaero 1342, Seongnam, 13120, Republic of Korea.
Herein, NaCl-templated mesoporous hard carbons (NMCs) have been designed and engineered with tunable surface properties as anode materials for potassium-ion batteries (KIBs) and hybrid capacitors (KICs). By utilizing "water-in-oil" emulsions, the size of NaCl templates is precisely modified, leading to smaller particles that enable the formation of primary carbon structures with reduced particle size and secondary structures with 3D interconnected mesoporosity. These features significantly enhance electrode density, reduce particle-to-particle resistance, and improve electrolyte wettability.
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