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Mapping the HPV Landscape in South African Women: A Systematic Review and Meta-Analysis of Viral Genotypes, Microbiota, and Immune Signals.
Viruses
December 2024
Discipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg 3209, South Africa.
This systematic review and meta-analysis evaluate human papillomavirus (HPV) prevalence, genotype distribution, and associations with cervicovaginal microbiota and cytokine profiles among South African women, where cervical cancer ranks as the second most common cancer. PubMed, SCOPUS, and Web of Science were searched for studies on HPV infection up to 21 September 2024. The pooled prevalence was estimated using a random-effects model, with subgroup analyses by province, sample type, and HIV status.
View Article and Find Full Text PDFChallenges in Global Distribution and Equitable Access to Monkeypox Vaccines.
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November 2024
Seventh-Day Adventist College of Nursing, Ile-Ife 220103, Nigeria.
The monkeypox outbreak has grown beyond the regions in which it was considered endemic. It has spread from central and west Africa to non-endemic regions like Europe, America, and other parts of the world. It has recently been classified as a public health emergency of international concern.
View Article and Find Full Text PDFEnhanced Immune Response Against Echinococcus Granulosus Through a CTLA-4/B7 Affinity-Based Vaccine.
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December 2024
Clinical Laboratory Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Echinococcosis is a zoonotic infectious disease that poses a significant threat to the health of individuals living in rural regions. While vaccination represents a potential strategy for disease prevention, there is currently no effective vaccine available for humans to prevent cystic echinococcosis (CE). This study aimed to design a novel multi-epitope vaccine (MEV) against Echinococcus granulosus for human use, employing immunoinformatics methods.
View Article and Find Full Text PDFResuspended Nano-Minerals in Coal Ash: A Potential Factor in Elevated Lung Cancer Rates in Xuanwei and Fuyuan, Yunnan, China.
Toxics
December 2024
State Key Laboratory of Coal Resources and Safe Mining & College of Geosciences and Surveying Engineering, China University of Mining and Technology, Beijing 100083, China.
Xuanwei and the neighboring Fuyuan (XF) counties in Yunnan Province have the highest lung cancer incidence rates in China. Previous studies suggest that the nano-minerals released during the combustion of locally sourced "smoky" (bituminous) coal are the primary contributors to these elevated cancer rates. The coal ash generated during combustion predominantly consists of nano-minerals, which can be resuspended into the atmosphere during routine ash-handling activities.
View Article and Find Full Text PDFBody Weight Changes During Childhood and Predictors of Excessive Body Weight in Adolescence-A Longitudinal Analysis.
Nutrients
December 2024
Department of Pediatrics, Gastroenterology, Allergology and Nutrition, Faculty of Medicine, Medical University of Gdańsk, 80-803 Gdańsk, Poland.
Abnormal body weight, including overweight and obesity, is a common health problem affecting children and adolescents. The present study aimed to analyse weight changes in children from preschool age to adolescence and to identify early predictors of excessive weight in adolescence, such as blood pressure and physical fitness observed in preschool children. Data from 3075 children (1524 girls and 1594 boys), collected as part of the Gdańsk Centre for Health Promotion's "Your Child's Healthy Life" programme, were analysed, with each child assessed at ages 6, 10, and 14.
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