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Anti-KRAS G12C and Anti-EGFR Rechallenge in Chemotherapy-Refractory G12C-Mutated Colorectal Cancer: A Case Report.
JCO Precis Oncol
December 2024
Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Development and Validation of Dynamic 5-Year Breast Cancer Risk Model Using Repeated Mammograms.
JCO Clin Cancer Inform
December 2024
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St Louis, MO.
Article Synopsis
- Current long-term risk prediction models for breast cancer are not fully utilizing past mammogram images, and dynamic models have not been explored for routine medical use.
- A study examined a large group of women, analyzing their mammogram data over time to create a dynamic model that predicts the 5-year risk of developing breast cancer.
- The results showed that incorporating previous mammogram images significantly improved risk prediction, identifying high-risk women who could benefit from further screening or preventive measures.
Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young- and Average-Onset Gastric Cancer.
Cancer Med
December 2024
Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Background: There has been a paradoxical rise in young-onset gastric cancer (YOGC), defined as gastric cancer (GC) diagnosed before age 50. Precursor lesions may contribute to pathogenesis, though their role in progression to different histologic subtypes is unclear. The impact of self-reported race is also poorly characterized and may be unreliable as a proxy for genetic differences.
View Article and Find Full Text PDFTreatment of scoliosis in children after resection of neuroblastoma-A report of five cases.
J Child Orthop
December 2024
Department of Orthopaedics, Beijing Children's Hospital, National Center for Children's Health, Beijing, China.
Article Synopsis
- * A study evaluated five patients who developed spinal deformities post-NB resection, using techniques like growing rods, spinal fusion, and casting, achieving significant improvement in their conditions.
- * It's recommended to monitor spinal deformities closely and start treatment within 6 months of diagnosis, tailoring the approach based on the patient's growth potential and skeletal maturity.
Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis: One Decade Later.
J Clin Oncol
December 2024
UCLA Fielding School of Public Health, David Geffen School of Medicine at UCLA, and the Jonsson Comprehensive Cancer Center, Los Angeles, CA.
In 2012, the National Academies of Sciences, Engineering, and Medicine convened a committee charged with addressing the quality of cancer care in the United States and providing recommendations to policymakers and the cancer care community on strategies to improve cancer care delivery from the time of diagnosis through end-of-life. The resulting committee report, titled (2013), presented a conceptual framework that included six interconnected components of care with corresponding recommendations. Over the past decade, the delivery of high-quality of cancer care has become more challenging and increasingly demanding on the workforce.
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