AI Article Synopsis
- Transcription factors regulate key cellular processes through post-translational modifications (PTMs), which are crucial for understanding gene regulation networks.
- PTMs influence drug responses and play a vital role in the prognosis of serious diseases, which highlights their importance in drug design focused on transcription factors.
- Current research is just starting to uncover the intricate relationship between PTMs, normal development, and disease, indicating there's much more to learn in this field.
Article Abstract
Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation via post-translational modifications (PTMs). Thus, decoding the combinations of PTMs should provide critical layer of information that can be integrated into highly specific cellular outputs to reveal a network of genes and their target-specific regulation. Protein modifications play a decisive role in various drug responses and eventually in prognosis for many life-threatening diseases, and recent studies demonstrate that TF-based drug designing must consider structural and functional changes due to PTMs, yet we are just beginning to grasp this enormity and the impact on normal development and disease pathophysiology.
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| http://dx.doi.org/10.2174/1874467207666140307124241 | DOI Listing |
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