AI Article Synopsis
- * A notable reaction sequence led to the creation of a betulin-derived amine dimer, while other methods produced an imidazo derivative.
- * Anticancer tests showed significant growth inhibition in various modified betulin compounds against both murine and human cell lines, highlighting the potential of the betulin structure for cancer treatment.
Article Abstract
The lupane-type triterpene betulin (1) has been subjected to a series of structural modifications for the purpose of evaluating resultant cancer cell growth inhibitory activity. The reaction sequence 7→11→12 was especially noteworthy in providing a betulin-derived amine dimer. Other unexpected synthetic results included the 11 and 13/14→17 conversions, which yielded an imidazo derivative. X-ray crystal structures of dimer 12 and intermediate 25 are reported. All of the betulin modifications were examined for anticancer activity against the P388 murine and human cell lines. Significant cancer cell growth inhibition was found for 4, 8, 9, 15/16, 19, 20, 24, and 26, which further defines the utility of the betulin scaffold.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010298 | PMC |
| http://dx.doi.org/10.1021/np400947d | DOI Listing |
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