Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973097 | PMC |
| http://dx.doi.org/10.1172/JCI67226 | DOI Listing |
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