Simulation of optical signaling among nano-bio-sensors: enhancing of bioimaging contrast.

In this article, the nanoparticle-dye systems is designed and simulated to illustrate the possibility of enhancement in optical imaging contrast. For this, the firefly optimization technique is used as an optical signaling mechanism among agents (nanoparticle-dye) because fireflies attract together due to their flashing light and optical signaling that is produced by a process of bioluminescence (also it has been investigated that other parameters such as neural response and brain function have essential role in attracting fireflies to each other). The first parameter is coincided with our work, because the nanoparticle-dye systems have ability to augment of received light and its amplification cause that the designed complex system act as a brightness particle. This induced behavior of nanoparticles can be considered as an optical communication and signaling. Indeed by functionalization of nanoparticles and then due to higher brightness of the tumor site because of active targeting, the other particles can be guided to reach toward the target point and the signaling among agents is done by optical relation similar to firefly nature. Moreover, the fundamental of this work is the use of surface plasmon resonance and plasmons hybridization, in which photonic signals can be manipulated on the nanoscale and can be used in biomedical applications such as electromagnetic field enhancement. Finally, it can be mentioned that by simultaneously using plasmon hybridization, near-field augmentation, and firefly algorithm, the optical imaging contrast can be impressively improved.