A method based on phase-shifting Fizeau interferometry is presented with which retroreflectors with large incoming-outgoing beam separations can be tested. The method relies on a flat Reference Bar that is used to align two auxiliary mirrors parallel to each other to extend the aperture of the interferometer. The method is applied to measure the beam coalignment of a prototype Triple Mirror Assembly of the GRACE Follow-On Laser Ranging Interferometer, a future satellite-to-satellite tracking device for Earth gravimetry. The Triple Mirror Assembly features a lateral beam offset of incoming and outgoing beam of 600 mm, whereas the acceptance angle for the incoming beam is only about ±2 mrad. With the developed method, the beam coalignment of the prototype Triple Mirror Assembly was measured to be 9 μrad with a repeatability of below 1 μrad.
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http://dx.doi.org/10.1063/1.4866682 | DOI Listing |
Introduction: Anterior cruciate ligament (ACL) reconstruction involves prolonged rehabilitation, with Return to Sport (RTS) as a key goal for athletes. Integrating Dual Task (DT) strategies, which combine cognitive and physical tasks, is critical, as multitasking mirrors real-world and sports-specific demands. Assessing how distractions affect performance is essential to optimize RTS outcomes for both the reconstructed and healthy limbs.
View Article and Find Full Text PDFFront Immunol
December 2024
Department of Surgery, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
Introduction: Despite recent advances, triple-negative breast cancer (TNBC) patients remain at high risk for recurrence and metastasis, which creates the need for innovative therapeutic approaches to improve patient outcomes. Cryoablation is a promising, less invasive alternative to surgical resection, capable of inducing tumor necrosis via freeze/thaw cycles. Necrotic cell death results in increased inflammatory signals and release of preserved tumor antigens, which have the potential to boost the local and systemic anti-tumor immune response.
View Article and Find Full Text PDFCancer Diagn Progn
November 2024
Oncomedicare Oncology Group, Thessaloniki, Greece.
Background/aim: Breast cancer remains a significant health challenge, with neoadjuvant chemotherapy (NACT) improving clinical outcomes in certain subtypes. However, the role of NACT in hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer is unclear due to various outcomes and generally low rates of pathologic complete response (pCR). This study introduces the Non-Luminal Disease Score (NOLUS) as a potential predictive tool for assessing the response to NACT in these cases.
View Article and Find Full Text PDFElife
November 2024
Multicellular Organization Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Mishima, Japan.
Organogenesis requires the proper production of diverse cell types and their positioning/migration. However, the coordination of these processes during development remains poorly understood. The gonad in exhibits a mirror-symmetric structure guided by the migration of distal tip cells (DTCs), which result from asymmetric divisions of somatic gonadal precursors (SGPs; Z1 and Z4).
View Article and Find Full Text PDFCase Rep Oncol
October 2024
Department of Internal Medicine, New York-Presbyterian Brooklyn Methodist Hospital Brooklyn, Brooklyn, NY, USA.
Introduction: Inflammatory breast cancer is a rare and aggressive subtype, with high breast cancer mortality. Compared to noninflammatory breast cancer, even after treatment and response to standard-of-care breast cancer chemotherapy, it has a high propensity for lymph node involvement, high rates of distant metastasis, and shorter survival. The immune checkpoint inhibitor, pembrolizumab, in combination with chemotherapy is now approved for early triple negative breast cancer (TNBC) and for advanced disease if positive for the programmed cell death ligand 1 protein (PD-L1).
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