AI Article Synopsis
- The study focuses on treatment options for patients with biochemical recurrence (BCR) of prostate cancer (PCa), emphasizing the development of therapeutic strategies since 2004.
- A retrospective analysis was conducted on 41 patients divided into three groups based on their initial treatments, with outcomes measured including BCR-free rates and biochemical response.
- Results showed that 56.1% of patients achieved BCR-freedom after salvage surgery, and the study concluded that salvage extended pelvic lymph node dissection (SePLND) may help reestablish sensitivity to androgen deprivation therapy (ADT), with a need for further multicenter research.
Article Abstract
Background. Treatment of patients with a biochemical recurrence (BCR) of prostate cancer (PCa) is generally difficult and without valid treatment options. Since 2004 we have been developing therapeutic possibilities for these patients. Methods. We retrospectively analyzed a cohort of 41 patients with a BCR of PCa and a mean followup of 40.3 ± 20.8 months. Group 1 (n = 10): salvage radical prostatectomy (sRP) with SePLND (salvage extended pelvic lymph nodes dissection) (initial treatment: combined brachytherapy). Group 2 (n = 22): SePLND (initial treatment: radical prostatectomy (RP)). Group 3 (n = 9): SePLND (initial treatment: RP and adjuvant radiation therapy (RT)). We observed PSA, PSA-velocity, localization of LNs and LNs+, BCR-free period, and BR (biochemical response). Results. Group 1: 60% with BCR-freedom (mean 27.2 months). Group 2: 63.6% with BCR-freedom (mean 17.5 months). Group 3: 33.3% with BCR-freedom (mean 17.6 months). In total, BCR-freedom was observed in 23 of 41 patients (56.1%) after salvage surgery. 75.6% of all patients showed a BR. 765 LNs were removed and 14.8% of these were LN+. Conclusions. The BCR-free period and BR are comparable in all three groups. Sensibility to ADT can be reestablished and prolonged as a result of SePLND. Multicenter studies are needed for a reliable output.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945023 | PMC |
| http://dx.doi.org/10.1155/2014/321619 | DOI Listing |
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