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Prospects of elafibranor in treating alcohol-associated liver diseases.
World J Gastroenterol
January 2025
School of Basic Medicine, Qilu Medical University, Zibo 255300, Shandong Province, China.
Alcohol-related liver disease (ALD), which is induced by excessive alcohol consumption, is a leading cause of liver-related morbidity and mortality. ALD patients exhibit a spectrum of liver injuries, including hepatic steatosis, inflammation, and fibrosis, similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis, metabolic dysfunction-associated steatotic liver disease, and nonalcoholic steatohepatitis. Elafibranor has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and cell models of metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis.
View Article and Find Full Text PDFComments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema.
F1000Res
January 2025
Department of Anatomy, Miyazaki University, Miyazaki, Miyazaki Prefecture, 889-1692, Japan.
This correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE). The study emphasizes shared proinflammatory pathways and T-cell-related gene upregulation while detailing unique features such as neutrophil involvement in PPP and lipid antigen processing in DPE.
View Article and Find Full Text PDFA long-ignored skeletal tissue filled with oil.
Science
January 2025
Program in Craniofacial Biology, Department of Orofacial Sciences, Department of Anatomy, Institute for Human Genetics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Lipid-rich cartilage points to nonmetabolic functions of lipid vacuoles in mammals.
View Article and Find Full Text PDFOn the origin of fatty acid biosynthesis in Archaeplastida.
J Exp Bot
January 2025
Department for Plant Biochemistry, University of Goettingen, Albrecht-von-Haller-Institute for Plant Sciences, Justus-von-Liebig-Weg 11, D-37077 Goettingen, Germany.
This article comments on: . 2025. Genomic and biochemical analyses of lipid biosynthesis in : limited role of the chloroplast in fatty acid synthesis.
View Article and Find Full Text PDFImprovement strategies for fats and oils used in future food processing based on health orientation and sustainability: research progress, challenges and solutions.
Crit Rev Food Sci Nutr
December 2024
Zhengzhou Xuemailong Food Flavor Co. R&D Center, Zhengzhou, Henan, China.
As the third largest source of energy in addition to carbohydrates and proteins, lipids provide the body with more than twice as much energy as carbohydrates and proteins and are the accumulated "fuel bank" of the body. They are widely stored in animals, plants and microorganisms and are effectively extracted for dietary use by improved and novel technologies. Under the pressure of the current environment, we should immediately look for new strategies to improve or develop dietary lipids that are compatible with the development of the future food industry, in order to mitigate the environmental and climatic degradation caused by the lipid-producing activities of the animal husbandry industry, to avoid the contradiction between the demand for high quality of human beings and the strain on the resources, and to reduce the health risks caused by saturated fats and trans-fats in meat products.
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