Mimicking the nanostructure of bone matrix to regenerate bone.

Mater Today (Kidlington)

Department of Biologic and Materials Sciences, University of Michigan, 1011 North University Ave., Room 2209, Ann Arbor, MI 48109, USA ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA ; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Published: November 2013

Key features of bone tissue structure and composition are capable of directing cellular behavior towards the generation of new bone tissue. Bone tissue, as well as materials derived from bone, have a long and successful history of use as bone grafting materials. Recent developments in design and processing of synthetic scaffolding systems has allowed the replication of the bone's desirable biological activity in easy to fabricate polymeric materials with nano-scale features exposed on the surface. The biological response to these new tissue-engineering scaffold materials oftentimes exceeds that seen on scaffolds produced using biological materials.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968917PMC
http://dx.doi.org/10.1016/j.mattod.2013.11.001DOI Listing

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