AI Article Synopsis
- The study examined the protective effects of 6'-O-galloylpaeoniflorin on human HaCaT keratinocytes exposed to ultraviolet B (UVB) radiation.
- The compound was found to effectively scavenge reactive oxygen species (ROS) and reduce oxidative damage to cellular components like DNA, lipids, and proteins caused by UVB exposure.
- Additionally, 6'-O-galloylpaeoniflorin prevented cell death by inhibiting the mitochondrial apoptotic pathway, suggesting its potential as a treatment for ROS-related skin conditions.
Article Abstract
The cytoprotective effects of 6'-O-galloylpaeoniflorin against injury and death of human HaCaT keratinocytes resulting from ultraviolet B radiation were investigated. 6'-O-galloylpaeoniflorin exhibited the capacity to scavenge intracellular reactive oxygen species (ROS) generated by ultraviolet B radiation. 6'-O-galloylpaeoniflorin also attenuated ultraviolet B-induced oxidative macromolecular damage to DNA, lipids, and proteins, decreasing the number of DNA strand breaks, the level of 8-isoprostane (a biomarker of lipid peroxidation), and the level of protein carbonylation. Moreover, 6'-O-galloylpaeoniflorin rescued HaCaT cells from ultraviolet induced cell death, by downregulating the mitochondrial apoptotic pathway. Taken together, these results indicate that 6'-O-galloylpaeoniflorin has the potential to be developed as a medical agent against ROS-mediated skin diseases.
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| http://dx.doi.org/10.1007/s11626-014-9747-0 | DOI Listing |
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