AI Article Synopsis
- Chronic fatigue can increase the risk of cardiovascular disease, but antioxidants like quercetin-3-O-gentiobiose (QG), found in okra, may help prevent this.
- In a rat study, doses of QG (25-75 mg/kg) improved endurance, reduced serum lactic acid, and lowered blood urea nitrogen levels.
- QG also showed beneficial effects by protecting blood vessels, boosting antioxidant enzyme activity, and reducing inflammatory cytokines, suggesting its potential use for treating fatigue-related heart issues.
Article Abstract
Chronic fatigue accumulation increases the incidence of cardiovascular disease while the treatment of antioxidants could prevent this development. We have previously shown that quercetin-3-O-gentiobiose (QG), a flavonoid isolated from tonic herb Okra, possesses anti-oxidative properties. In the present study, the protective effects of QG were evaluated in a rat model of load-induced endurance swimming. Oral administration of QG at the doses of 25-75mg/kg could significantly improve the endurance capability of rats to fatigue along with decrease serum lactic acid and blood urea nitrogen levels were decreased. Moreover, QG could alleviate vascular impairments, enhance the activities of antioxidant enzymes and attenuate the levels of inflammatory cytokines (MCP-1, IL-6 and TNF-α). The results indicated that QG had anti-fatigue and vasoprotective effects and represented a potential agent for the treatment of aortic pathology involved with fatigue- and related syndrome.
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| http://dx.doi.org/10.1016/j.fct.2014.03.026 | DOI Listing |
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