Objective: Chemerin is a recently identified adipocytokine that has been positively correlated with the presence and severity of coronary artery disease (CAD). However, no studies have examined circulating chemerin levels as a predictor of acute coronary syndrome (ACS). The purpose of this study is to evaluate whether chemerin levels predict the onset of ACS.
Materials/methods: We studied 90 men whose serum had been collected at least 2 years before the development of ACS, and 162 controls matched with the cases in a 1:2 fashion for age and year of collection. The mean age of the cohort was 66.3±9.6 years (range 34-84 years). Serum chemerin levels were measured with a commercially available enzyme-linked immunosorbent assay.
Results: Age was positively associated with chemerin levels (r=0.39, p<0.001). Logistic regression analysis, adjusting for years since blood collection, demonstrated a null association between chemerin levels and the odds ratio for development of ACS (OR: 0.99, 95% CI [0.99-1.001]). This association remained null after adjusting for age (OR: 0.99 95% CI [0.99-1.001]).
Conclusions: Although cross-sectional and case-control studies suggest a positive association between chemerin levels and CAD, we demonstrate that chemerin levels do not predict the development of ACS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.metabol.2014.02.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis.
Commun Biol
December 2024
Department of Nephrology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Acute kidney injury (AKI) is a common and life-threatening condition associated with cell death, where ferroptosis plays a critical role. Chemerin, primarily produced in white adipose tissue, has multiple biological functions in renal pathophysiology. However, to date, whether and how chemerin regulates the progression of AKI remain unclear.
View Article and Find Full Text PDFNew aspect on the regulation of in vitro oocyte maturation: role of the obesity, neuropeptides and adipokines.
J Assist Reprod Genet
December 2024
Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University in Krakow, 30-387, Krakow, Poland.
Oocyte quality determinants and nuclear and cytoplasmic maturation establish essential processes for fertilization and further development of the conceptus. Moreover, female fertility is strongly dependent on the metabolic status of the organism. Numerous sources indicate that obesity impairs ovarian function including oocyte physiology by inhibiting nuclear maturation, stimulating lipotoxicity and inflammation, enabling cumulus cells apoptosis, promoting reactive oxygen species formation and ultimately imposing pathogenic effects on mitochondria leading to infertility.
View Article and Find Full Text PDFThe Role of Chitinase 3-Like-1 (YKL-40) and Proinflammatory Biomarkers in the Pathogenesis of Pediatric Tick-Borne Encephalitis in a Polish Cohort.
J Inflamm Res
December 2024
Department of Pediatric Infectious Diseases, Medical University of Bialystok, Bialystok, Poland.
Background: Chitinase 3-like-1 (CHI3L1), also known as YKL-40, is a potential biomarker for neuroinflammatory conditions. It is upregulated in Alzheimer's disease, multiple sclerosis, and traumatic brain injury. However, its involvement in pediatric tick-borne encephalitis (TBE) has not been addressed yet.
View Article and Find Full Text PDFSerum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level.
Arch Med Sci
October 2024
Endoscopy Unit, Department of Internal Medicine and Geriatrics, Medical College Jagiellonian University, University Hospital, Krakow, Poland.
Article Synopsis
- The study aimed to investigate chemerin levels as a potential marker for diagnosing early-stage hepatocellular carcinoma (HCC) and determining its severity.
- The research included 76 patients, with 45 diagnosed with HCC (some having single lesions and others with metastasis) and 21 with isolated cirrhosis, alongside a control group of 10 healthy individuals.
- Results showed that chemerin levels were higher in patients with HCC compared to those with cirrhosis only and tended to decrease with worsening liver function, indicating its potential use in HCC diagnosis and staging.
Chemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet.
Mol Med
November 2024
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Article Synopsis
- High glucose levels in gestational diabetes mellitus (GDM) lead to oxidative stress in the placenta, which is critical for the development of the condition.
- The study explored the effects of the adipokine chemerin on oxidative stress in placental cells and established a GDM animal model to assess its impacts in vivo.
- Results showed that chemerin can reduce oxidative stress markers, improve antioxidant capacity, and lower blood glucose levels in pregnant mice with GDM, highlighting its potential therapeutic role.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!